High throughput analysis for early drug discovery
This book offers concise and unbiased presentations by synthetic and analytical chemists who have been involved in creating and moving the field of combinatorial chemistry into the academic and industrial mainstream. Since the synthetic method often dictates the appropriate types of analysis, each chapter or section begins with a description of the synthesis approach and its advantages. The description of various combinatorial and high-throughput parallel synthesis techniques provide a relevant point of entry for synthetic chemists who need to set up appropriate characterisation methods for his/her organisation. This is an invaluable resource for all organic and analytical chemists in the pharmaceutical, agrochemical, and biotechnology fields who are either involved in, or beginning to investigate combinatorial techniques to increase overall efficiency and productivity. First reference to focus on the analytical side of synthesis
Internet Resources
1 online resource (xv, 186 pages) : illustrations (some color)
9780124311657, 9780080472928, 0124311652, 0080472923
162129223
High Throughput Analysis of Combinatorial Libraries Encoded with Electrophoric Molecular Tags, Adolor Corporation
Analysis of a Combinatorial Library Synthesized Using a Split-and-pool Irori MicroKan Method for Development and Production, Boehringer Ingelheim Pharmaceuticals, Inc
High-Throughput Mass Spectrometry-Flow Injection Analysis, Procter and Gamble Pharmaceuticals
High-Throughput Flow-Injection ESI and APCI Mass Spectrometry for Combinatorial Chemistry: Automated Acquisition and Interpretation for Multi-Sprayer Low-Resolution and FTMS High-Resolution Exact-Mass Measurements, Wyeth Research
Purity and Quantity Determination of Parallel Synthesis Compound Libraries, ArQule, Inc
High-Throughput Parallel LC/MS/ELSD of Combinatorial Libraries Using the Eight-Channel LCT System With MUX Technology, Nereus Pharmaceuticals Inc and University of California, San Diego
Purification and Analysis of Parallel Libraries, Albany Molecular
Screening Single Bead Combinatorial Libraries Using Capillary HPLC and MALDI-TOF-MS, National Research Council
The Role of NMR in the Analysis of Chemical Libraries, Bristol Meyers Squibb
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