The Laboratory RatMark A. Suckow, Steven H. Weisbroth, Craig L. Franklin Elsevier, 2005 M12 20 - 928 pages The Laboratory Rat, Second Edition features updated information on a variety of topics including: rat genetics and genomics, both spontaneous and induced disease; state-of-the-art technology for housing and husbandry; occupational health, and experimental models. A premier source of information on the laboratory rat that will be of interest to veterinary and medical students, senior graduate, graduate students, post-docs and researchers who utilize animals in biomedical research.
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Page 129
... BLOOD, URINE COLLECTION AND SAMPLE HANDLING A. Collection of Blood To ensure the correct values are obtained for clinical pathology analytes, appropriate quality control of sample collection handling is required. Overnight fasting ...
... BLOOD, URINE COLLECTION AND SAMPLE HANDLING A. Collection of Blood To ensure the correct values are obtained for clinical pathology analytes, appropriate quality control of sample collection handling is required. Overnight fasting ...
Page 130
... BLOOD COAGULATION Clinical chemistry tests Effect of hemolysis Effect of freezing AST " none ALT " none SDH " # LDH " # ALP # none CK " # Kþ " none Bilirubin " none Albumin " none Glucose " none Hematology tests MCH " – MCHC ...
... BLOOD COAGULATION Clinical chemistry tests Effect of hemolysis Effect of freezing AST " none ALT " none SDH " # LDH " # ALP # none CK " # Kþ " none Bilirubin " none Albumin " none Glucose " none Hematology tests MCH " – MCHC ...
Page 131
... BLOOD COAGULATION A. HematologyTests Hematology data are generally collected by highly automated instrumentation that differentiates and quantifies the formed elements in blood based on their size, internal structures, staining, and/or ...
... BLOOD COAGULATION A. HematologyTests Hematology data are generally collected by highly automated instrumentation that differentiates and quantifies the formed elements in blood based on their size, internal structures, staining, and/or ...
Page 132
... BLOOD Cells in peripheral blood Life-span or half-life Blood cells Mature erythrocyte Life-span 42–65 days Reticulocyte Life-span 1–1.5 days Neutrophil Life-span 6 hours Monocyte Life-span $18 hours* Lymphocytes Life-span 60–100 days ...
... BLOOD Cells in peripheral blood Life-span or half-life Blood cells Mature erythrocyte Life-span 42–65 days Reticulocyte Life-span 1–1.5 days Neutrophil Life-span 6 hours Monocyte Life-span $18 hours* Lymphocytes Life-span 60–100 days ...
Page 134
... blood smears or bone marrow cytology. For the pharmaceutical industry, hematologic information generated by hematology analyzers is inconsistently obtained in carcinogenicity studies, although peripheral blood smears are frequently ...
... blood smears or bone marrow cytology. For the pharmaceutical industry, hematologic information generated by hematology analyzers is inconsistently obtained in carcinogenicity studies, although peripheral blood smears are frequently ...
Contents
53 | |
71 | |
93 | |
127 | |
147 | |
165 | |
8 Analysis of Behavior in Laboratory Rats | 191 |
9 Nutrition | 219 |
18 Experimental Modeling and Research Methodology | 587 |
19 Anesthesia and Analgesia | 627 |
20 Euthanasia and Necropsy | 665 |
21 Integrating Biology with Rat Genomic Tools | 679 |
22 Gnotobiotics | 693 |
23 Spontaneous Surgically and Chemically Induced Models of Disease | 711 |
24 The Nude Rat | 733 |
25 Gerontology and AgeAssociated Lesions | 761 |
10 Housing and Environment | 303 |
11 Bacterial Mycoplasmal and Mycotic Infections | 339 |
12 Viral Disease | 423 |
13 Parasitic Diseases | 453 |
14 Neoplastic Disease | 479 |
15 Metabolic Traumatic and Miscellaneous Diseases | 513 |
16 Medical Management and Diagnostic Approaches | 547 |
17 Occupational Health and Safety | 565 |
26 Cardiovascular Research | 773 |
27 Toxicology | 803 |
28 Embryology and Teratology | 817 |
29 Immunology | 847 |
30 Wild and Black Rats | 865 |
Appendix 1 Selected Normative Data | 883 |
Index | 885 |
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acid activity albino altered appear associated behavior Biol blood body bone brain breeding cage calcium cancer cause cells changes chemical clinical colony compared concentrations containing decreased deficiency detection determine diet dietary disease effects environment et al experimental factors female function gene genetic gland glucose growth Health host housed human immune important inbred incidence increased indicate induced infection influence Institute intestinal involved iron isolated Laboratory Animal laboratory rats lesions levels liver male metabolism methods mice mouse natural normal Nutr Nutrition observed occur organism Pneumocystis Press prevent production protein rats fed reduced reported reproductive respiratory response rodents role selected serum showed shown species spontaneous strains studies tion tissue treatment tumors University virus vitamin Wistar