Textbook of Biological PsychiatryJaak Panksepp John Wiley & Sons, 2004 M02 15 - 736 pages A Textbook of Biological Psychiatry integrates the basic science concerning brain mechanisms of psychiatric disorders alongside surveys of present standard clinical treatment. Organized in a coherent and easy to follow structure, chapters expand across different levels of analysis, from basic mechanisms to clinical practice. This comprehensive reference provides an integrative treatment of the biochemistry of neurotransmission, behavioral pharmacology, and clinical aspects of psychiatric problems including depression, manic-depression, and mood disorders. Other chapters address the biological mechanisms and treatment of depression, anxiety, panic, obsessive-compulsive disorder, and addictions. The editor concludes with a perspective on the future of the field and prospects for understanding and effectively treating mood and anxiety disorders. |
Contents
Part II CORE PSYCHIATRIC CHALLENGES | 195 |
Part III FUTURE PROSPECTS | 487 |
Appendix A PHARMACODYNAMICS AND PHARMACOKINETICS | 661 |
Index | 683 |
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abnormalities action activity agents amygdala animal antidepressant antipsychotic anxiety appears Arch areas associated attention basic behavioral biological blood brain cause changes Chapter Clin clinical clomipramine cognitive common consciousness correlates cortex cortical decreased deficits dementia demonstrated depression disease disorder dopamine dose drugs early effects efficacy emotional et al evidence example experience expression factors fear feelings findings forms frontal function genes genetic glucose human imaging impairment important increased individuals involved lesions levels major measures mechanisms medication memory mental mood nature neural neurons Neurosci normal observed organism panic disorder Panksepp patients percent personality potential prefrontal present Press problems processes produce Psychiatry PTSD recent receptors reduced regions reported response risk role schizophrenia selective serotonin severe social specific stimulation stress structures studies subjects suggest symptoms syndrome therapy traumatic treated treatment understanding University various York
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Page 232 - In children and adolescents, can be irritable mood. 2) markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day...
Page 233 - The mood disturbance is sufficiently severe to cause marked impairment in occupational functioning or in usual social activities or relationships with others, or to necessitate hospitalization to prevent harm to self or others, or there are psychotic features.
Page 232 - The symptoms are not due to the direct physiological effects of a substance (eg, a drug of abuse, a medication) or a general medical condition (eg, hypothyroidism) . E.
Page 233 - Distinct period of abnormally and persistently elevated, expansive, or irritable mood lasting at least 1 week (or any duration if hospitalization is necessary). B. During the period of mood disturbance, three (or more) of the following symptoms have persisted (four if the mood is only irritable) and have been present to a significant degree: 1. Inflated self-esteem or grandiosity 2. Decreased need for sleep (eg, feels rested after only 3 hours of sleep) 3.
Page 233 - ... of sleep) (3) more talkative than usual or pressure to keep talking (4) flight of ideas or subjective experience that thoughts are racing (5) distractibility (ie, attention too easily drawn to unimportant or irrelevant external stimuli) (6) increase in goal-directed activity (either socially, at work or school, or sexually) or psychomotor agitation (7) excessive involvement in pleasurable activities that have a high potential for painful consequences (eg, engaging in unrestrained buying sprees,...
Page 232 - C The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning...
Page 479 - Report of the Quality Standards Subcommittee of the American Academy of Neurology.
Page 232 - Five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure.
Page 232 - Insomnia or hypersomnia nearly every day 5 Psychomotor agitation or retardation nearly every day (observable by others, not merely subjective feelings of restlessness or being slowed down) 6 Fatigue or loss of energy nearly every day 7 Feelings of worthlessness or excessive or inappropriate guilt (which may be delusional) nearly every day (not merely self-reproach or guilt about being sick...