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" Because of the high potency of the drug and the variability of its potential to cause adverse reactions, the following are strongly recommended: 1) the lowest possible effective dose for the individual patient should be prescribed. Increased dosage tends... "
Competitive Problems in the Drug Industry - Page 1460
by United States. Congress. Senate. Select Committee on Small Business. Subcommittee on Monopoly - 1968
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Regional Export Expansion: Hearings, Ninetieth Congress, First ..., Volume 7

United States. Congress. Senate. Select Committee on Small Business - 1967 - 366 pages
...treatment of the disorders for which it is indicated. The revised package insert stressed that the "drug should not be prescribed for children because safe conditions for use have not been estnblishpd." It noted that "in a few cases of severe juvenile rheumatoid arthritis who were receiving...
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Competitive Problems in the Drug Industry, Parts 6-7

United States. Congress. Senate. Select Committee on Small Business. Subcommittee on Monopoly - 1968 - 1020 pages
...asthmatics. The safety of Indocin for use during pregnancy or lactation has not been established. The drug should not be prescribed for children because safe conditions for use have not been established. In a few cases of severe juvenile rheumatoid arthritis who were receiving Indocin along with other...
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