Assessing Quality of Life in Clinical Trials: Methods and Practice

"Quality of life assessment has progressed considerably since the publication of the highly acclaimed first edition of this book in 1998. Quality of life has now became an indispensable outcome measure in many randomized clinical trials and other studies. Thus it is timely to provide not just an update, but a completely new edition that reviews the current state of the art and also discusses topical issues including areas where active research is in progress. The first section discusses the development and evaluation of generic and disease-targeted questionnaires. Having helped the reader to decide on the items to be included, the thrust of the next section shows how to convert these into usable forms. Section 3, addressing analysis and how to analyse studies with missing data, is followed by chapters on interpretation of results, and the role of single-item questions. The final section of the book goes beyond the individual clinical trial and looks at how we can use clinical trial and other data to make macro-decisions." (Back cover).