Molecular Biology in Blood TransfusionCees Smit Sibinga, Harvey G. Klein Springer Science & Business Media, 2000 M09 30 - 284 pages The international symposia on blood transfusion in Groningen have taken place without interruption since 1976. Each year Dr. Smit-Sibinga and his team have not only organized a meeting on timely topics in blood transfusion, but also succeeded in attracting prominent chairmen and speakers. The subject of the 24th Symposium was Molecular Biology in Blood Transfusion and it was chaired by Dr. Harvey G. Klein, National Institutes of Health, USA. In this book of proceedings an extraordinary range of subjects is covered, including diagnostic aspects, virology, quality control, cell and protein processing as well as a section on new horizons in clinical medicine. |
Contents
Molecular Biology in Blood Transfusion Introduction | 3 |
Advances in Blood Grouping The Molecular Biology Approach | 13 |
Molecular Biology in Parentage Testing and Forensic Medicine | 35 |
Towards a Universal Blood Group Manipulating the Molecular Structure of Blood Group Antigens | 55 |
HLA and HPA Typing Advances in the Application of Molecular Biology | 61 |
Discussion | 73 |
Nucleic Acid Testing NAT of Blood and Plasma Donors | 81 |
Routine Experience and Future Developments in Virus NAT Application | 105 |
Application of Molecular Biology in Stem Cell Transplantation | 171 |
The In Vitro Effect of Cytokines on Expansion and Maturation of Megakaryocyte Progenitor Cells | 175 |
A Closed Culture System for the Ex Vivo Transduction and Expansion of Human T Lymphocytes | 187 |
Recombinant Products for Haemostasis StructureFunction Relationship | 203 |
Application of Molecular Biology in the Engineering of IV Immunoglobulins | 211 |
Discussion | 225 |
Targeted Immunotherapy The Use of Dendritic Cells in Tumor Vaccines | 235 |
Use of In Vitro and In Vivo Genetically Manipulated Cells for Immunotherapy of Cancer | 243 |
Lateral Flow | 111 |
The Relevance of Platelet CD62p Pselectin Testing | 125 |
The Recipient Mechanisms of Platelet Alloimmunisation | 135 |
Towards Standardisation of CD34+ Cell Enumeration in Stem Cell Harvesting and Processing | 147 |
Discussion | 159 |
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Common terms and phrases
Acad Sci USA alleles alloantibodies amplification analysis assay autologous Blood Bank blood group blood group antigens blood group system Blood Transfusion bone marrow C.Th cancer CD34+ cell clinical clone cord blood culture CXCR4 cytokines dendritic cells detection developed disease DNA typing donations encoded enzyme epitopes expression factor IX factor VIII gene genetic genome genotyping glycophorin GvHD haemophilia human immune response Immunol infection laboratory lymphocytes markers megakaryocyte progenitors megakaryocytes membrane methods MHC class molecular biology molecules monoclonal antibody mutations Natl Acad Sci nucleic acid nucleotide P-selectin parentage testing patients peptides peripheral blood phage display phenotype plasma platelets polymerase polymorphism pool primers probes Proc Natl Acad progenitor cells protein RBCs reaction receptor recipients red cell RFLP samples sequence Smit Sibinga specific stem cell T-clone target therapy tion Tissue transplantation tumor vaccines viral vitro window period