MAJOR FUNCTIONS AND ACTIVITIES (Include COSATI Codes): The Addiction Research Center has laboratories of neuropharmacology, which has both neurochemistry and neuropharmacology units, pharmacology, drug metabolism and kinetics, experimental psychiatry, neuropharmacology, bio-chemical pharmacology, psychopharmacology and clinical psychology. These laboratories are supported by an administrative service, research service and biophysics unit. In these areas of research the most exciting developments have been the study of partial agonists of the morphine type as well as the assessment of barbituratelike drugs on post-rotational nystagmus. Studies have also been conducted with the end of showing that the LSD type of psychotogen exerts its effects through inner action with a tryptamine receptor and these studies are being pursued with the end of further delineating the location of tryltaminergic receptor responses in the cat spinal cord. The sleep laboratory has been conducting studies of the nature of the rapid eye movement homeostat and the effects of narcotics on rapid eye movement sleep. Using self-injection techniques, studies are being conducted on the pattern of relapse to morphine in dogs. To further assess the addict's perception of the effects of drugs, extensive studies have been conducted in which patients have been asked to simulate drug effects and under such conditions their subjective esponses have been sampled. 06-01 Biological & Medical Sciences - Biochemistry) (06-03 Biological & Medical ciences - Biology) (06-05 Biological & Medical Sciences Clinical Medicine) 06-15 Biological & Medical Sciences Pharmacology) (06-16 Biological & Medical ciences Physio ADDITIONAL COSATI CODES: SURVEY OF FEDERAL GOVERNMENT RESEARCH AND DEVELOPMENT LABORATORIES Conducted By THE NATIONAL SCIENCE FOUNDATION For The FEDERAL COUNCIL FOR SCIENCE AND TECHNOLOGY 557 558 Laboratory contains a variety of chemical pharmacologicalm neurophysiological and psychological equipment. 9. COMMENT AND PUBLICATION REFERENCES: Projects described in NIMH Annual Reports. 1. P. O. ADDRESS: _Antigen Laboratory Unit, TB Branch, National Communicable Disease Center De Kalb (County) Extraction of skin-test materials from crude culture filtrates, mostly from various strains and special mycobacteria. Preparation and bottling of dilutions of skin-test materials for distribution and use by researchers in the USA and abroad. 559 560 Semi-automated equipment for preparation of large numbers of vials of skintest materials 9. COMMENT AND PUBLICATION REFERENCES: None. P. O. ADDRESS: Saint Elizabeths Hospital, Wm. A. White Bldg., Plans and conducts a program of basic research, both clinical and nonclinical, in such specialized areas as psychopharmacology, neuropharmacology, memory, human behavior, and the biochemistry of learning. These studies are directed at elucidating (1) the mechanisms of actions of various pharmacological agents and the affects of such agents on CNS activity; (2) the elationship of the metabolism of psychotropic drugs to the behavioral action aused by administration of such drugs; (3) the effect of conditioning on developing nd modifying patterns of behavior; and (4) the role of biochemical and biophysical rocesses in the development and maintenance of learned behavior. (06-01 Biological & Medical Sciences - Biochemistry, 06-05 Clinical Medicine, 06-15 Pharmacology, 06-16 Physiology; (05-10 Behavioral & Social Sciences Psychology). ADDITIONAL COSATI CODES: SURVEY OF FEDERAL GOVERNMENT RESEARCH AND DEVELOPMENT LABORATORIES Conducted By THE NATIONAL SCIENCE FOUNDATION For The FEDERAL COUNCIL FOR SCIENCE AND TECHNOLOGY 561 |