4. P. O. ADDRESS: Bureau of Radiological Health, ECA, CPEHS, 12720 Twinbrook Pkwy.

The Radiation Bio-effects Laboratory studies the biological effects of
ionizing and non-ionizing radiation, including investigations in the areas of
neurophysiology, pathology, metabolism, toxicology, dosimetry, epidemiology,
and genetics, as they relate to radiological health. (06-18, 20-05, 20-06, 20-14).
The BRH X-ray Exposure Control Laboratory designs and carries through research
and development projects to reduce X-ray exposure from medical, dental, and
industrial X-ray equipment; tests and evaluates various techniques and equipment
used with X-ray procedures; recommends changes in procedures and equipment aimed
at reducing X-ray exposure; promotes methods and concepts not in general use
which would reduce radiation exposure significantly (06-18, 20-08, 18-06).

The Electronic Products Laboratory plans and carries out design, development,
testing and evaluation of instrumentation and methodology for the detection and
measurement of electronic product radiation, and provides electronic product
radiation calibration and dosimetry services to designated activities.
(06-18, 20-05, 20-06, 20-14).

Laboratory resources are also used to investigate the modification caused by other environmental stresses of the biological effects produced by all types of electromagnetic and sonic radiation. (06-18, 20-05, 20-06, 20-14).

ADDITIONAL COSATI CODES:

SURVEY OF FEDERAL GOVERNMENT RESEARCH AND DEVELOPMENT LABORATORIES
Conducted By THE NATIONAL SCIENCE FOUNDATION For The

FEDERAL COUNCIL FOR SCIENCE AND TECHNOLOGY

497

498

The laboratories have the equipment and facilities for mounting a research and development program involving multi-disciplinary approaches to problems of radiological health. Major equipment includes:

Irradiation facilities (x-y ultraviolet, microwave infrared).

X-ray sources with electron beam currents from a nanoampere to 50 milliamperes, and accelerating potentials from a few kV to 250 kV.

9. COMMENT AND PUBLICATION REFERENCES:

The Bureau publishes a periodical "The BRH Bulletin," which is available upon request.

The Bureau has three field laboratories, which carry out a large and diverse research and development program. These are:

Northeast Radiological Health Laboratory, Winchester, Massachusetts
Southeast Radiological Health Laboratory, Montgomery, Alabama
Southwestern Radiological Health Laboratory, Las Vegas, Nevada

The Bureau has two subsidiary laboratories in Cincinnati, Ohio. These are:

Radiological Engineering Laboratory
Radiological Health Laboratory

These are subsidiary organizations to the Bureau of Radiological Health.

. P. O. ADDRESS:

A.

Bureau of Science, Food & Drug Admin., CPEHS, 200 C St., S.W.

Div. of Pharmaceutical Sciences: Conducts research on methods of trace drug detection (06-01), occurrence and measurement of toxic substances in drug products (07-04), develops criteria for drug standards and purity tests (07-03), and conducts research on methods of assaying insulin and antibiotics in drugs (06-01, 07-03, 07-04). Div. of Colors and Cosmetics: Conducts research on the chemistry and reactions of olors and cosmetics; develops methods for their detection and analysis (07-04). iv. of Food Chemistry and Technology: Conducts research on and develops analytical ethods for hazardous substances in food; develops standards for identity, quality, nd quantity for food products (07-03, 07-04, 07-05).

iv. of Nutrition: Conducts research on the nature and effects of nutritionally ignificant substances in foods and drugs; develops analytical and detection ethods (06-01).

iv. of Pharmacology and Toxicology: Conducts research on the nature of pharmacologially and toxicologically significant substances in food and drugs and their effects a biological systems (06-15, 06-20).

v. of Microbiology: Conducts research on the nature, extent, causes, and signifince of microbial contaminants in foods and drugs; develops methods for detection d prevention of food poisoning, and for microbiological analysis of foods, drugs, d cosmetics (06-13).

v. of Pesticides: Conducts research on the nature, behavior, and occurrence of sticides and their degradation products in man and the environment and the hazards acute and chronic exposure. Develops and evaluates methods for detection of sticides and their degradation products in foods and feeds (06-01, 06-03, 06-20, -03, 07-04).

SURVEY OF FEDERAL GOVERNMENT RESEARCH AND DEVELOPMENT LABORATORIES

Conducted By THE NATIONAL SCIENCE FOUNDATION For The

FEDERAL COUNCIL FOR SCIENCE AND TECHNOLOGY

SFL 1

499

500

The Bureau of Science Laboratories maintain a variety of equipment normally found
in research laboratories of these types. Special equipment includes:

Small pilot food preparation, canning, and thermal processing plant.
Nuclear magnetic resonance spectrometers.

A "clean" room for examination of parenteral preparations for sterility.

9. COMMENT AND PUBLICATION REFERENCES:

The Food and Drug Administration has a variety of publications available from its
Information Center, Federal Bldg. 8, Rm. 1812, 200 C St., Washington, D.C. 20204.
FDA PAPERS, the official publication of FDA (10 issues per year) is available from
the Superintendent of Documents, Government Printing Office ($6.00 per year).

In addition to the organizational laboratories listed on the preceding page, the
Bureau of Science has several subsidiary research and development laboratories
as follows:

National Center for Drug Analysis, St. Louis, Missouri
Milk and Food Laboratories, Cincinnati, Ohio

Toxicology Laboratory, Chamblee, Georgia

National Center for Microbiological Analysis, Minneapolis, Minnesota
Perrine Primate Laboratory, Perrine, Florida

National Center for Antibiotic and Insulin Analysis, Washington, D.C.

4. P. O. ADDRESS: Bureau of Water Hygiene, ECA, CPEHS, 5555 Ridge Avenue

c. Ohio

(State)

513-684-2200 x4201

(Telephone (Area Code & No.)

6. FUNDING (Approximate FY 1969 Dollar Obligation):
A. INTRAMURAL (Total):

461,890

B. EXTRAMURAL (Total):

7. MAJOR FUNCTIONS AND ACTIVITIES (Include COSATI Codes):

This laboratory is concerned primarily with research and development on
water supply reservoir management, water quality deterioration in distribution
systems, chemical analyses, and methodology for quantifying agents of public
health importance in drinking and recreational waters. (08-08, 13-02)

A. ADDITIONAL COSATI CODES:

SURVEY OF FEDERAL GOVERNMENT RESEARCH AND DEVELOPMENT LABORATORIES

Conducted By THE NATIONAL SCIENCE FOUNDATION For The

FEDERAL COUNCIL FOR SCIENCE AND TECHNOLOGY

501