The Dog and Its GenomeElaine A. Ostrander, Urs Giger, Kerstin Lindblad-Toh Cold Spring Harbor Laboratory Press, 2006 - 584 pages Dogs of different breeds can range remarkably in size, shape, and behavior, and yet they all carry essentially the same genome, making them a particularly fascinating model for genome plasticity. The recent release of the complete sequence of the dog genome provides an exciting new context in which to consider such variation. Twenty–five chapters written by experts in the field include various aspects of morphological and behavioral variation in dogs, their origins and domestication, and their unique value as a model system for many common but complex human diseases such as diabetes and cancer. |
Contents
BREED CLUBS AND CANINE HISTORY | 1 |
The Kennel Club and the Early History of Dog Shows | 19 |
American Breed Clubs and Health Initiatives | 31 |
Copyright | |
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activity addition affected alleles American analysis animals approach associated Bedlington Bedlington terriers behavior cancer candidate canine cause cell changes chromosome clade clinical clones Club common comparative complex copper toxicosis detection determined disease disorders diversity dog breeds domestic dog dysplasia early et al evidence evolution example expression factor Figure function gene genetic genome groups growth haplotypes human identified increased indicated individuals inherited involved Labrador levels linkage loci locus major male mapping markers molecular morphological mouse mtDNA mutation normal observed occurs origin Ostrander pedigree phenotype polymorphism population present Press produced progressive protein recent receptor region represent response retinal retriever Science selection sequence similar single spaniel species structure studies suggests terriers traits tumors types University variation wolf wolves