The Laboratory Rat: Research applicationsHenry J. Baker, James Russell Lindsey, Steven H. Weisbroth Academic Press, 1980 - 276 pages |
From inside the book
Results 1-3 of 89
Page 111
... effects in hu- mans . Data from these studies also provide useful insight into the design of human trials and can help to predict what effects might be expected in initial clinical studies in humans . Since rodent and nonrodent species ...
... effects in hu- mans . Data from these studies also provide useful insight into the design of human trials and can help to predict what effects might be expected in initial clinical studies in humans . Since rodent and nonrodent species ...
Page 114
... effects of high doses of the new drug , and in this way provide fundamental data for the design of more complex animal studies ( 39 ) . The simplest acute toxicity trial is an LD50 . This is a single dosing of five or six groups of 10 ...
... effects of high doses of the new drug , and in this way provide fundamental data for the design of more complex animal studies ( 39 ) . The simplest acute toxicity trial is an LD50 . This is a single dosing of five or six groups of 10 ...
Page 115
... effects of the test chemical on the male and female repro- ductive systems . At the same time , the drug is studied for any potentially harmful effects on the developing fetus when the dam is dosed during a specific period of pregnancy ...
... effects of the test chemical on the male and female repro- ductive systems . At the same time , the drug is studied for any potentially harmful effects on the developing fetus when the dam is dosed during a specific period of pregnancy ...
Contents
Identification Methods | 4 |
Substance Administration | 19 |
Contents of Volume I | 38 |
Copyright | |
11 other sections not shown
Other editions - View all
Common terms and phrases
Academic Press adult agents albino rat Anat anesthesia anesthetic animal model antibody antigens Arch artery biochemical Biol blastocyst blood pressure BN/Bi body weight cage Cancer Cancer Res cannulation carcinogenesis carcinogens carcinomas cardiac caries cavity cells chemical chronic Clin dental dental caries diet disease dose drug duct effect embryo enzymes Ethylenethiourea evaluation experimental factors female flora genetic germfree germfree rats GF rats gland gnotobiotic growth human hypertension hypertrophy immune implantation inbred induced infection isolator laboratory animals laboratory rat lesions liver Long-Evans lymph lymphocytes male malformations metabolism method mice molars mouse myocardium myocytes N. Y. Acad Natl neoplasms normal oral organ Pathol Pathology Physiol placenta Proc procedure protein rodents salivary specific spontaneous Sprague-Dawley studies technique teratogenic Teratology thoracic duct tion tissue toxicity transplantable trophoblast trypan blue tumors ventricle vitamin vitro WAG/Rij Wistar Wistar rats yolk sac