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Page 112
Type of study Number of animals used Acute studies LD 50 , single dose , 14 - day observation 50-60 50-60 50-60 6-8 5 / sex / level , 3 dose levels Dose range , 14 days consecutive dosing 2 / sex / level , 2-3 dose levels Subchronic ...
Type of study Number of animals used Acute studies LD 50 , single dose , 14 - day observation 50-60 50-60 50-60 6-8 5 / sex / level , 3 dose levels Dose range , 14 days consecutive dosing 2 / sex / level , 2-3 dose levels Subchronic ...
Page 114
50 Table IV ( Continued ) dosage group is determined . If one of the dosage groups has an exact 50 % mortality , the LD50 is readily approximated . In most mg of the free base . In the report , the dose will be stated as the base ( or ...
50 Table IV ( Continued ) dosage group is determined . If one of the dosage groups has an exact 50 % mortality , the LD50 is readily approximated . In most mg of the free base . In the report , the dose will be stated as the base ( or ...
Page 265
Table I ( Continued ) Drug Classification Dosage Comment Reference Mustard Miscellaneous irritant 43 ... week Dose prevented body weight gain 0.02 % of feed Dose prevented body weight gain mg / kg po 3x / week Dose prevented body weight ...
Table I ( Continued ) Drug Classification Dosage Comment Reference Mustard Miscellaneous irritant 43 ... week Dose prevented body weight gain 0.02 % of feed Dose prevented body weight gain mg / kg po 3x / week Dose prevented body weight ...
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Contents
Substance Administration | 19 |
2 | 43 |
Contents of Volume I | 52 |
Copyright | |
14 other sections not shown
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Common terms and phrases
Acad activity addition adult agents antibody antigens appear Arch Biol blood body cages Cancer Cancer Res carcinogenesis carcinogens carcinomas cells changes chemical collection compared compounds continued described determine diet disease dose drug duct effects embryo evaluation experimental experiments exposure factors female function genetic germfree gland groups growth heart host human immune Immunol inbred incidence increased induced infection isolated Laboratory Animals laboratory rat lesions liver lymphocytes major male material method mg/kg mice months mouse natural normal observed obtained occur oral organ Pathology period placenta potential present Press Proc procedure produced Reference reported response selected skin species spontaneous strain studies surface Table technique teratogenic tion tissue toxicity transplantable tumors various weeks weight Wistar York
Bibliographic information
| Title | The Laboratory Rat: Research applications Volume 2 of American College of Laboratory Animal Medicine series, American College of Laboratory Animal Medicine Volume 2 of The Laboratory Rat, Steven H. Weisbroth The Laboratory Rat: Research Applications V. II, James Russell Lindsey |
| Editors | Henry J. Baker, James Russell Lindsey, Steven H. Weisbroth |
| Edition | illustrated |
| Publisher | Academic Press, 1980 |
| Original from | the University of Michigan |
| Digitized | 26 Feb 2010 |
| ISBN | 0120749025, 9780120749027 |
| Length | 276 pages |
| Export Citation | BiBTeX EndNote RefMan |