The Laboratory Rat: Research applicationsHenry J. Baker, James Russell Lindsey, Steven H. Weisbroth Academic Press, 1980 - 276 pages |
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Page 105
... altered organ functions ( which spe- cifically increase the sensitivity to the test drug ) are used in pharmacologic screening studies . Specific examples of these rat model systems are listed in Table I. Organs or tissues from normal ...
... altered organ functions ( which spe- cifically increase the sensitivity to the test drug ) are used in pharmacologic screening studies . Specific examples of these rat model systems are listed in Table I. Organs or tissues from normal ...
Page 110
... altered rats , or isolated organ or tissue assay preparations ( Table I ) . The mechanism for the development of drugs includes the submission of a Notice of Claim of Investigational Exemption for a New Drug ( IND ) to the FDA . This ...
... altered rats , or isolated organ or tissue assay preparations ( Table I ) . The mechanism for the development of drugs includes the submission of a Notice of Claim of Investigational Exemption for a New Drug ( IND ) to the FDA . This ...
Page 111
... altered to produce the desired or undesired effects at receptor sites is studied in this series of investigations ( 5,6,8 ) . Because the rat absorbs and eliminates many chemi- cals in a similar manner as man , the laboratory rat is ...
... altered to produce the desired or undesired effects at receptor sites is studied in this series of investigations ( 5,6,8 ) . Because the rat absorbs and eliminates many chemi- cals in a similar manner as man , the laboratory rat is ...
Contents
Identification Methods | 4 |
Substance Administration | 19 |
Contents of Volume I | 38 |
Copyright | |
11 other sections not shown
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Academic Press adult agents albino rat Anat anesthesia anesthetic animal model antibody antigens Arch artery biochemical Biol blastocyst blood pressure BN/Bi body weight cage Cancer Cancer Res cannulation carcinogenesis carcinogens carcinomas cardiac caries cavity cells chemical chronic Clin dental dental caries diet disease dose drug duct effect embryo enzymes Ethylenethiourea evaluation experimental factors female flora genetic germfree germfree rats GF rats gland gnotobiotic growth human hypertension hypertrophy immune implantation inbred induced infection isolator laboratory animals laboratory rat lesions liver Long-Evans lymph lymphocytes male malformations metabolism method mice molars mouse myocardium myocytes N. Y. Acad Natl neoplasms normal oral organ Pathol Pathology Physiol placenta Proc procedure protein rodents salivary specific spontaneous Sprague-Dawley studies technique teratogenic Teratology thoracic duct tion tissue toxicity transplantable trophoblast trypan blue tumors ventricle vitamin vitro WAG/Rij Wistar Wistar rats yolk sac