High Throughput Screening: The Discovery of Bioactive SubstancesCRC Press, 1997 M05 6 - 704 pages Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high |
From inside the book
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Page v
... target assays and has become the only investigational system available for discovery programs that address the inhibition of newly discovered enzyme and receptor targets . It will remain in this exclusive role until the emerging ...
... target assays and has become the only investigational system available for discovery programs that address the inhibition of newly discovered enzyme and receptor targets . It will remain in this exclusive role until the emerging ...
Page x
... Target selection III . Types and characteristics of screening assays IV . Decision making 16. Scintillation Proximity Assays Martino Picardo and Kelvin T. Hughes I. II . Introduction Automatability of SPA screening assays III . Assay ...
... Target selection III . Types and characteristics of screening assays IV . Decision making 16. Scintillation Proximity Assays Martino Picardo and Kelvin T. Hughes I. II . Introduction Automatability of SPA screening assays III . Assay ...
Page xii
... Target " versus " marker " approaches III . Development of a gene expression - based screen ( GEBS ) IV . Throughput of GEBS 401 413 25. High - Performance Microphysiometry in Drug Discovery ..... 427 M. Liisa Alajoki , Gregory T ...
... Target " versus " marker " approaches III . Development of a gene expression - based screen ( GEBS ) IV . Throughput of GEBS 401 413 25. High - Performance Microphysiometry in Drug Discovery ..... 427 M. Liisa Alajoki , Gregory T ...
Page 5
... target - specific microassays , automation / robotics technologies , and integrated data management that permits the bio- evaluation of > 1,000,000 test substances annually . In larger companies , such programs form the core of lead ...
... target - specific microassays , automation / robotics technologies , and integrated data management that permits the bio- evaluation of > 1,000,000 test substances annually . In larger companies , such programs form the core of lead ...
Page 8
... target for a three - year period ending in 1997. The permanent secretariat of the Convention was assigned as Montreal , Canada at the Jakarta meeting of the Parties . The text of the Convention on Biological Diversity is provided in ...
... target for a three - year period ending in 1997. The permanent secretariat of the Convention was assigned as Montreal , Canada at the Jakarta meeting of the Parties . The text of the Convention on Biological Diversity is provided in ...
Contents
Chemically Generated Screening Libraries | 145 |
Ill Assay Technologies and Detection Methods | 273 |
IV Automation and Robotics | 455 |
V Data Retrieval Handling and Integration | 547 |
VI Laboratory Design and Management | 623 |
Index | 669 |
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High Throughput Screening: The Discovery of Bioactive Substances John P. Devlin Limited preview - 1997 |
Common terms and phrases
acid actinomycetes activity analysis antibody applications approach assay assay plate bar-code BIAcore binding assay biochemical biological diversity cells chelates Chem chemical diversity collection combinatorial chemistry combinatorial libraries companies components compounds concentration Contracting Party Convention cryptate database detection DMSO drug discovery enzyme evaluated example extracts Figure FlashPlate fluorescence format function gene handling high throughput screening HTRF HTS program identified immunoassays implementation incubation inhibition inhibitors instruments integrated interface labeled laboratory large numbers ligand luciferase marine natural products methods microbial microorganisms microplate molecular molecules neurotrophin operation optimization Oracle peptide performed pharmaceutical polyphenols protein protocol radioligand reaction reagents receptor reporter gene resin robotic system samples scintillation screening data screening program secondary metabolites signal solid phase solution specific streptavidin structure substrate synthesis synthetic Table target trkB workstations