High Throughput Screening: The Discovery of Bioactive SubstancesCRC Press, 1997 M05 6 - 704 pages Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high |
From inside the book
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Page 3
... structural features that were accountable for new activity modes was most often serendipitous and rarely through deductive ... structure - based drug design as a multidimensional discipline wherein computational techniques supplement ...
... structural features that were accountable for new activity modes was most often serendipitous and rarely through deductive ... structure - based drug design as a multidimensional discipline wherein computational techniques supplement ...
Page 5
... structural and functional diversity but also one that requires a major commitment in staff , resources and ... structures and synthetic pathways are clearly defined and can be duplicated in the laboratory . Archival collections in ...
... structural and functional diversity but also one that requires a major commitment in staff , resources and ... structures and synthetic pathways are clearly defined and can be duplicated in the laboratory . Archival collections in ...
Page 10
... structures within a HTS discovery program , but not essential . If access to natural resources is available through ... structure for the drafting of a protocol for the transfer , handling , and use of living modified organisms ...
... structures within a HTS discovery program , but not essential . If access to natural resources is available through ... structure for the drafting of a protocol for the transfer , handling , and use of living modified organisms ...
Page 17
... structure categories of interest to the client . Compounds of designated chemical structures may also be custom synthesized . Various quantities are available , including , but not limited to 1-5 mg , 50-100 mgs , or gram quantities ...
... structure categories of interest to the client . Compounds of designated chemical structures may also be custom synthesized . Various quantities are available , including , but not limited to 1-5 mg , 50-100 mgs , or gram quantities ...
Page 19
... structure lists through their internet homepages for Europe ( http://www.unibase.ch/mdpi/database.htm ) and a parallel form for the Americas ( http://www.mdpi.org/database.htm ) . The list is updated monthly . Total repository is ...
... structure lists through their internet homepages for Europe ( http://www.unibase.ch/mdpi/database.htm ) and a parallel form for the Americas ( http://www.mdpi.org/database.htm ) . The list is updated monthly . Total repository is ...
Contents
Chemically Generated Screening Libraries | 145 |
Ill Assay Technologies and Detection Methods | 273 |
IV Automation and Robotics | 455 |
V Data Retrieval Handling and Integration | 547 |
VI Laboratory Design and Management | 623 |
Index | 669 |
Other editions - View all
High Throughput Screening: The Discovery of Bioactive Substances John P. Devlin Limited preview - 1997 |
Common terms and phrases
acid actinomycetes activity analysis antibody applications approach assay assay plate bar-code BIAcore binding assay biochemical biological diversity cells chelates Chem chemical diversity collection combinatorial chemistry combinatorial libraries companies components compounds concentration Contracting Party Convention cryptate database detection DMSO drug discovery enzyme evaluated example extracts Figure FlashPlate fluorescence format function gene handling high throughput screening HTRF HTS program identified immunoassays implementation incubation inhibition inhibitors instruments integrated interface labeled laboratory large numbers ligand luciferase marine natural products methods microbial microorganisms microplate molecular molecules neurotrophin operation optimization Oracle peptide performed pharmaceutical polyphenols protein protocol radioligand reaction reagents receptor reporter gene resin robotic system samples scintillation screening data screening program secondary metabolites signal solid phase solution specific streptavidin structure substrate synthesis synthetic Table target trkB workstations