High Throughput Screening: The Discovery of Bioactive SubstancesCRC Press, 1997 M05 6 - 704 pages Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high |
From inside the book
Results 1-5 of 77
Page xiv
... Programming considerations VII . Final summary points 36. Systems Integration ....... Chip Allee I. Introduction II . III . HTS Data Management Conclusion 525 549 551 583 37. Data Management and Tracking ... Program . Matthew Contents xiv.
... Programming considerations VII . Final summary points 36. Systems Integration ....... Chip Allee I. Introduction II . III . HTS Data Management Conclusion 525 549 551 583 37. Data Management and Tracking ... Program . Matthew Contents xiv.
Page xv
... screening program III . Samples for screening IV . Equipping the HTS laboratory V. Developing high throughput screens VI . Reagent supply VII . Data management VIII . Lead discovery 627 653 669 Taylor & Francis Taylor & Francis Group ...
... screening program III . Samples for screening IV . Equipping the HTS laboratory V. Developing high throughput screens VI . Reagent supply VII . Data management VIII . Lead discovery 627 653 669 Taylor & Francis Taylor & Francis Group ...
Page 4
... screening ( HTS ) was the result . HTS is based solely on statistics . The dedication of a screening program to one biochemical mechanism , for example , is less likely to succeed than a spectrum of assay targets in the therapeutic ...
... screening ( HTS ) was the result . HTS is based solely on statistics . The dedication of a screening program to one biochemical mechanism , for example , is less likely to succeed than a spectrum of assay targets in the therapeutic ...
Page 5
... programs and for that reason the technology has flourished . A modern , industrial HTS program is a composite of target - specific microassays , automation / robotics technologies , and integrated data management that permits the bio ...
... programs and for that reason the technology has flourished . A modern , industrial HTS program is a composite of target - specific microassays , automation / robotics technologies , and integrated data management that permits the bio ...
Page 7
... Programs in natural products , which offer the greatest opportunity for diversity , are ... screening resource and are accountable for most of the antibiotics in ... program . The greatest diversity in access , by far , lies in tropical ...
... Programs in natural products , which offer the greatest opportunity for diversity , are ... screening resource and are accountable for most of the antibiotics in ... program . The greatest diversity in access , by far , lies in tropical ...
Contents
Chemically Generated Screening Libraries | 145 |
Ill Assay Technologies and Detection Methods | 273 |
IV Automation and Robotics | 455 |
V Data Retrieval Handling and Integration | 547 |
VI Laboratory Design and Management | 623 |
Index | 669 |
Other editions - View all
High Throughput Screening: The Discovery of Bioactive Substances John P. Devlin Limited preview - 1997 |
Common terms and phrases
acid actinomycetes activity analysis antibody applications approach assay assay plate bar-code BIAcore binding assay biochemical biological diversity cells chelates Chem chemical diversity collection combinatorial chemistry combinatorial libraries companies components compounds concentration Contracting Party Convention cryptate database detection DMSO drug discovery enzyme evaluated example extracts Figure FlashPlate fluorescence format function gene handling high throughput screening HTRF HTS program identified immunoassays implementation incubation inhibition inhibitors instruments integrated interface labeled laboratory large numbers ligand luciferase marine natural products methods microbial microorganisms microplate molecular molecules neurotrophin operation optimization Oracle peptide performed pharmaceutical polyphenols protein protocol radioligand reaction reagents receptor reporter gene resin robotic system samples scintillation screening data screening program secondary metabolites signal solid phase solution specific streptavidin structure substrate synthesis synthetic Table target trkB workstations