High Throughput Screening: The Discovery of Bioactive SubstancesCRC Press, 1997 M05 6 - 704 pages Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high |
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Page iii
... pharmaceutical industry in whole animal and tissue models for half a century ( 1920-1970 ) with the result manifest in today's impressive armamentarium of drugs . During this period , discovery relied primarily on the sequential ...
... pharmaceutical industry in whole animal and tissue models for half a century ( 1920-1970 ) with the result manifest in today's impressive armamentarium of drugs . During this period , discovery relied primarily on the sequential ...
Page iv
... of this " high throughput screening " ( HTS ) and its adoption as the primary source of novel discovery in the pharmaceutical industry . The early attempts at HTS applications within the industrial environment Preface iv.
... of this " high throughput screening " ( HTS ) and its adoption as the primary source of novel discovery in the pharmaceutical industry . The early attempts at HTS applications within the industrial environment Preface iv.
Page xvii
... Pharmaceuticals , Ltd. , Mereside , Alderley Park , Macclesfield , Cheshire , SK10 4TG , UK . William R. Bemiss , Molecular Devices Corporation , 1311 Orleans Drive , Sunnyvale , California , 94089 , U.S.A. Maureen H. Beresini ...
... Pharmaceuticals , Ltd. , Mereside , Alderley Park , Macclesfield , Cheshire , SK10 4TG , UK . William R. Bemiss , Molecular Devices Corporation , 1311 Orleans Drive , Sunnyvale , California , 94089 , U.S.A. Maureen H. Beresini ...
Page xviii
... . Louis , Missouri , 63144 , U.S.A. Mark Crawford , Lasure and Crawford , Inc. , 130 Fifth Ave. North , Seattle , Washington , 98109 , U.S.A. Anthony W. Czarnik , Parke - Davis Pharmaceutical Research Division Contributors xviii.
... . Louis , Missouri , 63144 , U.S.A. Mark Crawford , Lasure and Crawford , Inc. , 130 Fifth Ave. North , Seattle , Washington , 98109 , U.S.A. Anthony W. Czarnik , Parke - Davis Pharmaceutical Research Division Contributors xviii.
Page xix
... Pharmaceutical Research Division of Warner- Lambert Company , 2800 Plymouth Road , Ann Arbor , Michigan , 48105 , U.S.A. Ferenc Darvas , ComGenex , Ltd. , P. O. Box 316 , H - 1393 , Budapest , Hungary . Timothy D. Dawes , Molecular ...
... Pharmaceutical Research Division of Warner- Lambert Company , 2800 Plymouth Road , Ann Arbor , Michigan , 48105 , U.S.A. Ferenc Darvas , ComGenex , Ltd. , P. O. Box 316 , H - 1393 , Budapest , Hungary . Timothy D. Dawes , Molecular ...
Contents
Chemically Generated Screening Libraries | 145 |
Ill Assay Technologies and Detection Methods | 273 |
IV Automation and Robotics | 455 |
V Data Retrieval Handling and Integration | 547 |
VI Laboratory Design and Management | 623 |
Index | 669 |
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High Throughput Screening: The Discovery of Bioactive Substances John P. Devlin Limited preview - 1997 |
Common terms and phrases
acid actinomycetes activity analysis antibody applications approach assay assay plate bar-code BIAcore binding assay biochemical biological diversity cells chelates Chem chemical diversity collection combinatorial chemistry combinatorial libraries companies components compounds concentration Contracting Party Convention cryptate database detection DMSO drug discovery enzyme evaluated example extracts Figure FlashPlate fluorescence format function gene handling high throughput screening HTRF HTS program identified immunoassays implementation incubation inhibition inhibitors instruments integrated interface labeled laboratory large numbers ligand luciferase marine natural products methods microbial microorganisms microplate molecular molecules neurotrophin operation optimization Oracle peptide performed pharmaceutical polyphenols protein protocol radioligand reaction reagents receptor reporter gene resin robotic system samples scintillation screening data screening program secondary metabolites signal solid phase solution specific streptavidin structure substrate synthesis synthetic Table target trkB workstations