High Throughput Screening: The Discovery of Bioactive SubstancesCRC Press, 1997 M05 6 - 704 pages Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high |
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Page iii
... operation . This screening mode was widely practiced in academia and industry especially in the period ( 1950-1970 ) when natural product research was pursued as an important resource for novel structures and activities . The cost was ...
... operation . This screening mode was widely practiced in academia and industry especially in the period ( 1950-1970 ) when natural product research was pursued as an important resource for novel structures and activities . The cost was ...
Page iv
... operations with multiple plates . A new segment of this industry evolved to meet these challenges and those anticipated from the further amplification of this " high throughput screening " ( HTS ) and its adoption as the primary source ...
... operations with multiple plates . A new segment of this industry evolved to meet these challenges and those anticipated from the further amplification of this " high throughput screening " ( HTS ) and its adoption as the primary source ...
Page v
... operations . The scientists who have grasped this multidisciplinary spirit are the leaders at the forefront of innovation in HTS and the ones who will open new and exciting doors to discovery . The purpose of this text is to provide an ...
... operations . The scientists who have grasped this multidisciplinary spirit are the leaders at the forefront of innovation in HTS and the ones who will open new and exciting doors to discovery . The purpose of this text is to provide an ...
Page 21
... operation has provided > 12,000 samples to academic , non - profit and for - profit organizations for screening related to AIDS , cancer and diseases of developing countries . In the initial program offering , a limit of 120-150 weighed ...
... operation has provided > 12,000 samples to academic , non - profit and for - profit organizations for screening related to AIDS , cancer and diseases of developing countries . In the initial program offering , a limit of 120-150 weighed ...
Page 31
... operations of the mechanism shall be carried out by such institutional structure as may be decided upon by the Conference of the Parties at its first meeting . For purposes of this Convention , the Conference of the Parties shall ...
... operations of the mechanism shall be carried out by such institutional structure as may be decided upon by the Conference of the Parties at its first meeting . For purposes of this Convention , the Conference of the Parties shall ...
Contents
Chemically Generated Screening Libraries | 145 |
Ill Assay Technologies and Detection Methods | 273 |
IV Automation and Robotics | 455 |
V Data Retrieval Handling and Integration | 547 |
VI Laboratory Design and Management | 623 |
Index | 669 |
Other editions - View all
High Throughput Screening: The Discovery of Bioactive Substances John P. Devlin Limited preview - 1997 |
Common terms and phrases
acid actinomycetes activity analysis antibody applications approach assay assay plate bar-code BIAcore binding assay biochemical biological diversity cells chelates Chem chemical diversity collection combinatorial chemistry combinatorial libraries companies components compounds concentration Contracting Party Convention cryptate database detection DMSO drug discovery enzyme evaluated example extracts Figure FlashPlate fluorescence format function gene handling high throughput screening HTRF HTS program identified immunoassays implementation incubation inhibition inhibitors instruments integrated interface labeled laboratory large numbers ligand luciferase marine natural products methods microbial microorganisms microplate molecular molecules neurotrophin operation optimization Oracle peptide performed pharmaceutical polyphenols protein protocol radioligand reaction reagents receptor reporter gene resin robotic system samples scintillation screening data screening program secondary metabolites signal solid phase solution specific streptavidin structure substrate synthesis synthetic Table target trkB workstations