High Throughput Screening: The Discovery of Bioactive SubstancesCRC Press, 1997 M05 6 - 704 pages Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high |
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Page iii
... product , is a commercial and beneficial success . This sequence of events was ... natural extracts in the classical assays ( tissues or whole animals ) ... marine natural products attracted the industrial scientist . Again cost and ...
... product , is a commercial and beneficial success . This sequence of events was ... natural extracts in the classical assays ( tissues or whole animals ) ... marine natural products attracted the industrial scientist . Again cost and ...
Page viii
... Marine Environment as a Discovery Resource Gregg R. Dietzman 99 I. Introduction II . Scope and diversity III . Access to marine natural products libraries IV . Economic concerns V. Requirements of an effective acquisition program VI ...
... Marine Environment as a Discovery Resource Gregg R. Dietzman 99 I. Introduction II . Scope and diversity III . Access to marine natural products libraries IV . Economic concerns V. Requirements of an effective acquisition program VI ...
Page 7
... marine world , which holds some of the most fascinating chemistry ... Natural products ( microbial , plant or marine ) are derived not only locally but also from international sources . Such ... Natural products V. International relationships.
... marine world , which holds some of the most fascinating chemistry ... Natural products ( microbial , plant or marine ) are derived not only locally but also from international sources . Such ... Natural products V. International relationships.
Page 10
... marine biodiversity , the marine ecosystems in general and the management of specific species and populations . Fishing issues , government subsidies and incentives were a part of these ... Natural Products as a Discovery Resource 10.
... marine biodiversity , the marine ecosystems in general and the management of specific species and populations . Fishing issues , government subsidies and incentives were a part of these ... Natural Products as a Discovery Resource 10.
Page 16
... Marine Organisms , D.G. Fauatin ( ed ) ; California Academy of Sciences ( 1988 ) . 5. Marine bacteria : Developing a new resource , Chem . Rev. 93 : 1673 ( 1993 ) . G.G. ... Natural Products as a Discovery Resource 16 VII. Conclusions.
... Marine Organisms , D.G. Fauatin ( ed ) ; California Academy of Sciences ( 1988 ) . 5. Marine bacteria : Developing a new resource , Chem . Rev. 93 : 1673 ( 1993 ) . G.G. ... Natural Products as a Discovery Resource 16 VII. Conclusions.
Contents
Chemically Generated Screening Libraries | 145 |
Ill Assay Technologies and Detection Methods | 273 |
IV Automation and Robotics | 455 |
V Data Retrieval Handling and Integration | 547 |
VI Laboratory Design and Management | 623 |
Index | 669 |
Other editions - View all
High Throughput Screening: The Discovery of Bioactive Substances John P. Devlin Limited preview - 1997 |
Common terms and phrases
acid actinomycetes activity analysis antibody applications approach assay assay plate bar-code BIAcore binding assay biochemical biological diversity cells chelates Chem chemical diversity collection combinatorial chemistry combinatorial libraries companies components compounds concentration Contracting Party Convention cryptate database detection DMSO drug discovery enzyme evaluated example extracts Figure FlashPlate fluorescence format function gene handling high throughput screening HTRF HTS program identified immunoassays implementation incubation inhibition inhibitors instruments integrated interface labeled laboratory large numbers ligand luciferase marine natural products methods microbial microorganisms microplate molecular molecules neurotrophin operation optimization Oracle peptide performed pharmaceutical polyphenols protein protocol radioligand reaction reagents receptor reporter gene resin robotic system samples scintillation screening data screening program secondary metabolites signal solid phase solution specific streptavidin structure substrate synthesis synthetic Table target trkB workstations