High Throughput Screening: The Discovery of Bioactive SubstancesCRC Press, 1997 M05 6 - 704 pages Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high |
From inside the book
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Page v
... integrated computer system . Such a system had to be compatible with the output of each assay and , once established , the design of new assays had to be tailored to meet these data - handling requirements . This aspect of compliance in ...
... integrated computer system . Such a system had to be compatible with the output of each assay and , once established , the design of new assays had to be tailored to meet these data - handling requirements . This aspect of compliance in ...
Page xiv
... Integration Edited by John P. Devlin 34. Introduction ....... John P. Devlin 35. Database Systems ..... Barr E. Bauer Introduction I. II . Database Architectures III . Client - server systems IV . Performance and design considerations V ...
... Integration Edited by John P. Devlin 34. Introduction ....... John P. Devlin 35. Database Systems ..... Barr E. Bauer Introduction I. II . Database Architectures III . Client - server systems IV . Performance and design considerations V ...
Page 5
... integrated data management that permits the bio- evaluation of > 1,000,000 test substances annually . In larger companies , such programs form the core of lead generation potential , whereas the existence and survival of the newer ...
... integrated data management that permits the bio- evaluation of > 1,000,000 test substances annually . In larger companies , such programs form the core of lead generation potential , whereas the existence and survival of the newer ...
Page 14
... integrate and propagate such information . Efforts are underway to resolve that problem and thereby to enhance the value of this resource . At Explorama Lodge near Iquitos , western and tribal experts are working together to amass a ...
... integrate and propagate such information . Efforts are underway to resolve that problem and thereby to enhance the value of this resource . At Explorama Lodge near Iquitos , western and tribal experts are working together to amass a ...
Page 36
... integration organizations , in matters within their competence , shall exercise their right to vote with a number of votes equal to the number of their member States which are Contracting Parties to this Convention or the relevant ...
... integration organizations , in matters within their competence , shall exercise their right to vote with a number of votes equal to the number of their member States which are Contracting Parties to this Convention or the relevant ...
Contents
Chemically Generated Screening Libraries | 145 |
Ill Assay Technologies and Detection Methods | 273 |
IV Automation and Robotics | 455 |
V Data Retrieval Handling and Integration | 547 |
VI Laboratory Design and Management | 623 |
Index | 669 |
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High Throughput Screening: The Discovery of Bioactive Substances John P. Devlin Limited preview - 1997 |
Common terms and phrases
acid actinomycetes activity analysis antibody applications approach assay assay plate bar-code BIAcore binding assay biochemical biological diversity cells chelates Chem chemical diversity collection combinatorial chemistry combinatorial libraries companies components compounds concentration Contracting Party Convention cryptate database detection DMSO drug discovery enzyme evaluated example extracts Figure FlashPlate fluorescence format function gene handling high throughput screening HTRF HTS program identified immunoassays implementation incubation inhibition inhibitors instruments integrated interface labeled laboratory large numbers ligand luciferase marine natural products methods microbial microorganisms microplate molecular molecules neurotrophin operation optimization Oracle peptide performed pharmaceutical polyphenols protein protocol radioligand reaction reagents receptor reporter gene resin robotic system samples scintillation screening data screening program secondary metabolites signal solid phase solution specific streptavidin structure substrate synthesis synthetic Table target trkB workstations