High Throughput Screening: The Discovery of Bioactive SubstancesCRC Press, 1997 M05 6 - 704 pages Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high |
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Page iv
... inhibitors of these enzymes and receptors . This approach , although still at the macroassay level , set the stage for the emergence of the discipline of biochemistry as an important partner in discovery within industrial programs . The ...
... inhibitors of these enzymes and receptors . This approach , although still at the macroassay level , set the stage for the emergence of the discipline of biochemistry as an important partner in discovery within industrial programs . The ...
Page v
... inhibition of newly discovered enzyme and receptor targets . It will remain in this exclusive role until the emerging technologies in computer - based molecular design can accurately predict structural features required for such ...
... inhibition of newly discovered enzyme and receptor targets . It will remain in this exclusive role until the emerging technologies in computer - based molecular design can accurately predict structural features required for such ...
Page 4
... inhibitor of an unknown receptor would require the evaluation of 400,000 structurally diverse entities . While the ... inhibitors of IL - 1 and IL - 2 are examples . More than ten years of screening by scores of pharmaceutical Natural ...
... inhibitor of an unknown receptor would require the evaluation of 400,000 structurally diverse entities . While the ... inhibitors of IL - 1 and IL - 2 are examples . More than ten years of screening by scores of pharmaceutical Natural ...
Page 15
... inhibitor of a newly discovered receptor is similarly an unlikely application of indigenous knowledge . Such limitations may be overcome if the test scope of a discovery program is very broad as in some HTS systems . In such instances ...
... inhibitor of a newly discovered receptor is similarly an unlikely application of indigenous knowledge . Such limitations may be overcome if the test scope of a discovery program is very broad as in some HTS systems . In such instances ...
Page 78
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Contents
Chemically Generated Screening Libraries | 145 |
Ill Assay Technologies and Detection Methods | 273 |
IV Automation and Robotics | 455 |
V Data Retrieval Handling and Integration | 547 |
VI Laboratory Design and Management | 623 |
Index | 669 |
Other editions - View all
High Throughput Screening: The Discovery of Bioactive Substances John P. Devlin Limited preview - 1997 |
Common terms and phrases
acid actinomycetes activity analysis antibody applications approach assay assay plate bar-code BIAcore binding assay biochemical biological diversity cells chelates Chem chemical diversity collection combinatorial chemistry combinatorial libraries companies components compounds concentration Contracting Party Convention cryptate database detection DMSO drug discovery enzyme evaluated example extracts Figure FlashPlate fluorescence format function gene handling high throughput screening HTRF HTS program identified immunoassays implementation incubation inhibition inhibitors instruments integrated interface labeled laboratory large numbers ligand luciferase marine natural products methods microbial microorganisms microplate molecular molecules neurotrophin operation optimization Oracle peptide performed pharmaceutical polyphenols protein protocol radioligand reaction reagents receptor reporter gene resin robotic system samples scintillation screening data screening program secondary metabolites signal solid phase solution specific streptavidin structure substrate synthesis synthetic Table target trkB workstations