High Throughput Screening: The Discovery of Bioactive SubstancesCRC Press, 1997 M05 6 - 704 pages Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high |
From inside the book
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Page iv
... screening . Even the sources for such isolations were frequently difficult to access and unpredictable in their ... high throughput screening " ( HTS ) and its adoption as the primary source of novel discovery in the pharmaceutical ...
... screening . Even the sources for such isolations were frequently difficult to access and unpredictable in their ... high throughput screening " ( HTS ) and its adoption as the primary source of novel discovery in the pharmaceutical ...
Page v
... HTS system had to comply with certain general design features if high throughput and efficiency were to be realized . Today , such designs have evolved into standard microassay format that can be tailored to identify numerous molecular ...
... HTS system had to comply with certain general design features if high throughput and efficiency were to be realized . Today , such designs have evolved into standard microassay format that can be tailored to identify numerous molecular ...
Page x
... High Throughput Screening for Leads Optimization ... 263 Richard M. Kris , Patti Willson , Serene Josiah , Marianne Wildgoose , Helen Yeoman , Viktor Krchnak , Stephen Baum , and Stephen Felder I. Introduction II . Sample screening ...
... High Throughput Screening for Leads Optimization ... 263 Richard M. Kris , Patti Willson , Serene Josiah , Marianne Wildgoose , Helen Yeoman , Viktor Krchnak , Stephen Baum , and Stephen Felder I. Introduction II . Sample screening ...
Page xii
... High Throughput Screening by FP 23. Reporter Gene Assay Applications .. Winfried Scheirer I. Introduction II . Reporter genes and their products III . Detection techniques and their improvement IV . Future aspects 24. Development of a ...
... High Throughput Screening by FP 23. Reporter Gene Assay Applications .. Winfried Scheirer I. Introduction II . Reporter genes and their products III . Detection techniques and their improvement IV . Future aspects 24. Development of a ...
Page xiii
... screening objectives III . Development of the screening infrastructure IV . Hardware V. Computing VI . Further development of the HTS facility Accelerating the Discovery Process with Automation and Robotics : A Sure Bet or a Risky ...
... screening objectives III . Development of the screening infrastructure IV . Hardware V. Computing VI . Further development of the HTS facility Accelerating the Discovery Process with Automation and Robotics : A Sure Bet or a Risky ...
Contents
Chemically Generated Screening Libraries | 145 |
Ill Assay Technologies and Detection Methods | 273 |
IV Automation and Robotics | 455 |
V Data Retrieval Handling and Integration | 547 |
VI Laboratory Design and Management | 623 |
Index | 669 |
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High Throughput Screening: The Discovery of Bioactive Substances John P. Devlin Limited preview - 1997 |
Common terms and phrases
acid actinomycetes activity analysis antibody applications approach assay assay plate bar-code BIAcore binding assay biochemical biological diversity cells chelates Chem chemical diversity collection combinatorial chemistry combinatorial libraries companies components compounds concentration Contracting Party Convention cryptate database detection DMSO drug discovery enzyme evaluated example extracts Figure FlashPlate fluorescence format function gene handling high throughput screening HTRF HTS program identified immunoassays implementation incubation inhibition inhibitors instruments integrated interface labeled laboratory large numbers ligand luciferase marine natural products methods microbial microorganisms microplate molecular molecules neurotrophin operation optimization Oracle peptide performed pharmaceutical polyphenols protein protocol radioligand reaction reagents receptor reporter gene resin robotic system samples scintillation screening data screening program secondary metabolites signal solid phase solution specific streptavidin structure substrate synthesis synthetic Table target trkB workstations