High Throughput Screening: The Discovery of Bioactive SubstancesCRC Press, 1997 M05 6 - 704 pages Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high |
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Page xii
... Gene Assay Applications .. Winfried Scheirer I. Introduction II . Reporter genes and their products III . Detection techniques and their improvement IV . Future aspects 24. Development of a Gene Expression - Based Screen Using ...
... Gene Assay Applications .. Winfried Scheirer I. Introduction II . Reporter genes and their products III . Detection techniques and their improvement IV . Future aspects 24. Development of a Gene Expression - Based Screen Using ...
Page 4
... gene expression in the control or progression of disease is catalogued and previously unknown macromolecules identified at the receptor or signal level . Such targets are anticipated to command an important role in future HTS designs ...
... gene expression in the control or progression of disease is catalogued and previously unknown macromolecules identified at the receptor or signal level . Such targets are anticipated to command an important role in future HTS designs ...
Page 7
... genes , fungi : 10,000 genes , plants : > 100,000 genes ) . The reason for this apparent paradox is that plant samples are far more difficult to acquire and , using classical techniques , have a much higher cost per sample basis ...
... genes , fungi : 10,000 genes , plants : > 100,000 genes ) . The reason for this apparent paradox is that plant samples are far more difficult to acquire and , using classical techniques , have a much higher cost per sample basis ...
Page 39
... genes of social , scientific or economic importance . Annex II Part 1 : ARBITRATION Article 1 The claimant party shall notify the secretariat that the parties are referring a dispute to arbitration pursuant to Article 27. The ...
... genes of social , scientific or economic importance . Annex II Part 1 : ARBITRATION Article 1 The claimant party shall notify the secretariat that the parties are referring a dispute to arbitration pursuant to Article 27. The ...
Page 82
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Contents
Chemically Generated Screening Libraries | 145 |
Ill Assay Technologies and Detection Methods | 273 |
IV Automation and Robotics | 455 |
V Data Retrieval Handling and Integration | 547 |
VI Laboratory Design and Management | 623 |
Index | 669 |
Other editions - View all
High Throughput Screening: The Discovery of Bioactive Substances John P. Devlin Limited preview - 1997 |
Common terms and phrases
acid actinomycetes activity analysis antibody applications approach assay assay plate bar-code BIAcore binding assay biochemical biological diversity cells chelates Chem chemical diversity collection combinatorial chemistry combinatorial libraries companies components compounds concentration Contracting Party Convention cryptate database detection DMSO drug discovery enzyme evaluated example extracts Figure FlashPlate fluorescence format function gene handling high throughput screening HTRF HTS program identified immunoassays implementation incubation inhibition inhibitors instruments integrated interface labeled laboratory large numbers ligand luciferase marine natural products methods microbial microorganisms microplate molecular molecules neurotrophin operation optimization Oracle peptide performed pharmaceutical polyphenols protein protocol radioligand reaction reagents receptor reporter gene resin robotic system samples scintillation screening data screening program secondary metabolites signal solid phase solution specific streptavidin structure substrate synthesis synthetic Table target trkB workstations