High Throughput Screening: The Discovery of Bioactive SubstancesCRC Press, 1997 M05 6 - 704 pages Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high |
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Page xiii
... Database : Key Components in a Radioligand Binding Program .... Elizabeth A. Kunysz , Melissa Lukes , and Douglas W. Bonhaus I. Introduction 483 II . Methods III . Discussion IV . Glossary of terms 31 . Factors for the Successful ...
... Database : Key Components in a Radioligand Binding Program .... Elizabeth A. Kunysz , Melissa Lukes , and Douglas W. Bonhaus I. Introduction 483 II . Methods III . Discussion IV . Glossary of terms 31 . Factors for the Successful ...
Page xiv
... Database Systems ..... Barr E. Bauer Introduction I. II . Database Architectures III . Client - server systems IV . Performance and design considerations V. Chemical structure databases VI . Programming considerations VII . Final ...
... Database Systems ..... Barr E. Bauer Introduction I. II . Database Architectures III . Client - server systems IV . Performance and design considerations V. Chemical structure databases VI . Programming considerations VII . Final ...
Page 19
... databases of chemicals available from stock in ZIOC ; c ) Russian plant products database ; d ) monthly updated lists of small quantity samples ( 20-500 mg ) immediately available with NMR- or mass - spectra ; and e ) substructure ...
... databases of chemicals available from stock in ZIOC ; c ) Russian plant products database ; d ) monthly updated lists of small quantity samples ( 20-500 mg ) immediately available with NMR- or mass - spectra ; and e ) substructure ...
Page 61
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Contents
Chemically Generated Screening Libraries | 145 |
Ill Assay Technologies and Detection Methods | 273 |
IV Automation and Robotics | 455 |
V Data Retrieval Handling and Integration | 547 |
VI Laboratory Design and Management | 623 |
Index | 669 |
Other editions - View all
High Throughput Screening: The Discovery of Bioactive Substances John P. Devlin Limited preview - 1997 |
Common terms and phrases
acid actinomycetes activity analysis antibody applications approach assay assay plate bar-code BIAcore binding assay biochemical biological diversity cells chelates Chem chemical diversity collection combinatorial chemistry combinatorial libraries companies components compounds concentration Contracting Party Convention cryptate database detection DMSO drug discovery enzyme evaluated example extracts Figure FlashPlate fluorescence format function gene handling high throughput screening HTRF HTS program identified immunoassays implementation incubation inhibition inhibitors instruments integrated interface labeled laboratory large numbers ligand luciferase marine natural products methods microbial microorganisms microplate molecular molecules neurotrophin operation optimization Oracle peptide performed pharmaceutical polyphenols protein protocol radioligand reaction reagents receptor reporter gene resin robotic system samples scintillation screening data screening program secondary metabolites signal solid phase solution specific streptavidin structure substrate synthesis synthetic Table target trkB workstations