High Throughput Screening: The Discovery of Bioactive SubstancesCRC Press, 1997 M05 6 - 704 pages Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high |
From inside the book
Results 1-5 of 81
Page iii
... cost was significant . As the limits of the models were reached , returns diminished and its application within the industrial setting disappeared . A revival of this mode of screening was enjoyed in the early seventies as the ...
... cost was significant . As the limits of the models were reached , returns diminished and its application within the industrial setting disappeared . A revival of this mode of screening was enjoyed in the early seventies as the ...
Page v
... costs and the speed of data return . The last item brought the final partner into the fold - data management . What could be handled efficiently before by a single scientist in a manual review of assay data had now become a task ...
... costs and the speed of data return . The last item brought the final partner into the fold - data management . What could be handled efficiently before by a single scientist in a manual review of assay data had now become a task ...
Page 5
... cost that was economically preferred over the do - it - yourself approach . Costs initially were low ( ~ $ 20 US per 50-100 mg sample ) and the numbers required were relatively small by today's standards . Terms of sale often included ...
... cost that was economically preferred over the do - it - yourself approach . Costs initially were low ( ~ $ 20 US per 50-100 mg sample ) and the numbers required were relatively small by today's standards . Terms of sale often included ...
Page 6
... cost several million dollars . Annual corporate budgets of $ 200,000 to $ 800,000 for synthetic compound acquisition are commonplace . These costs are amplified significantly by the additional expense of maintaining the staff required ...
... cost several million dollars . Annual corporate budgets of $ 200,000 to $ 800,000 for synthetic compound acquisition are commonplace . These costs are amplified significantly by the additional expense of maintaining the staff required ...
Page 7
... cost per sample basis . Companies who use plant - based natural product programs as a discovery resource invariably evaluate only a few hundred species a year . Even that level is a formidable challenge since each sample demands ...
... cost per sample basis . Companies who use plant - based natural product programs as a discovery resource invariably evaluate only a few hundred species a year . Even that level is a formidable challenge since each sample demands ...
Contents
Chemically Generated Screening Libraries | 145 |
Ill Assay Technologies and Detection Methods | 273 |
IV Automation and Robotics | 455 |
V Data Retrieval Handling and Integration | 547 |
VI Laboratory Design and Management | 623 |
Index | 669 |
Other editions - View all
High Throughput Screening: The Discovery of Bioactive Substances John P. Devlin Limited preview - 1997 |
Common terms and phrases
acid actinomycetes activity analysis antibody applications approach assay assay plate bar-code BIAcore binding assay biochemical biological diversity cells chelates Chem chemical diversity collection combinatorial chemistry combinatorial libraries companies components compounds concentration Contracting Party Convention cryptate database detection DMSO drug discovery enzyme evaluated example extracts Figure FlashPlate fluorescence format function gene handling high throughput screening HTRF HTS program identified immunoassays implementation incubation inhibition inhibitors instruments integrated interface labeled laboratory large numbers ligand luciferase marine natural products methods microbial microorganisms microplate molecular molecules neurotrophin operation optimization Oracle peptide performed pharmaceutical polyphenols protein protocol radioligand reaction reagents receptor reporter gene resin robotic system samples scintillation screening data screening program secondary metabolites signal solid phase solution specific streptavidin structure substrate synthesis synthetic Table target trkB workstations