High Throughput Screening: The Discovery of Bioactive SubstancesCRC Press, 1997 M05 6 - 704 pages Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high |
From inside the book
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Page 3
... company's ability to structurally modify known active molecules to yield a candidate with an improved activity ... companies relied upon the chemist's skills in synthesis and the pharmacologist's observational abilities to find the ...
... company's ability to structurally modify known active molecules to yield a candidate with an improved activity ... companies relied upon the chemist's skills in synthesis and the pharmacologist's observational abilities to find the ...
Page 4
... companies , is not . Such numbers , moreover , are meaningful only when they represent full distribution of chemical functionality through three dimensional space , that is , structural diversity . Exclusive assessment of compounds of a ...
... companies , is not . Such numbers , moreover , are meaningful only when they represent full distribution of chemical functionality through three dimensional space , that is , structural diversity . Exclusive assessment of compounds of a ...
Page 5
... companies , such programs form the core of lead generation potential , whereas the existence and survival of the newer discovery companies rely entirely on HTS technologies . The limiting factor to success in the discovery of new and ...
... companies , such programs form the core of lead generation potential , whereas the existence and survival of the newer discovery companies rely entirely on HTS technologies . The limiting factor to success in the discovery of new and ...
Page 6
... companies offering compound supplies for screening Company Aldrich location USA sources academia Bionet UK synthesis ... companies that offer such support ( e.g. , Table 1 ) . Another innovation was the formation of consortia of ...
... companies offering compound supplies for screening Company Aldrich location USA sources academia Bionet UK synthesis ... companies that offer such support ( e.g. , Table 1 ) . Another innovation was the formation of consortia of ...
Page 7
... companies as an integral part of their discovery matrix . It's impact in lead development , perhaps its most dramatic contribution , has been frequently demonstrated . IV . NATURAL PRODUCTS Programs in natural products , which offer the ...
... companies as an integral part of their discovery matrix . It's impact in lead development , perhaps its most dramatic contribution , has been frequently demonstrated . IV . NATURAL PRODUCTS Programs in natural products , which offer the ...
Contents
Chemically Generated Screening Libraries | 145 |
Ill Assay Technologies and Detection Methods | 273 |
IV Automation and Robotics | 455 |
V Data Retrieval Handling and Integration | 547 |
VI Laboratory Design and Management | 623 |
Index | 669 |
Other editions - View all
High Throughput Screening: The Discovery of Bioactive Substances John P. Devlin Limited preview - 1997 |
Common terms and phrases
acid actinomycetes activity analysis antibody applications approach assay assay plate bar-code BIAcore binding assay biochemical biological diversity cells chelates Chem chemical diversity collection combinatorial chemistry combinatorial libraries companies components compounds concentration Contracting Party Convention cryptate database detection DMSO drug discovery enzyme evaluated example extracts Figure FlashPlate fluorescence format function gene handling high throughput screening HTRF HTS program identified immunoassays implementation incubation inhibition inhibitors instruments integrated interface labeled laboratory large numbers ligand luciferase marine natural products methods microbial microorganisms microplate molecular molecules neurotrophin operation optimization Oracle peptide performed pharmaceutical polyphenols protein protocol radioligand reaction reagents receptor reporter gene resin robotic system samples scintillation screening data screening program secondary metabolites signal solid phase solution specific streptavidin structure substrate synthesis synthetic Table target trkB workstations