High Throughput Screening: The Discovery of Bioactive SubstancesCRC Press, 1997 M05 6 - 704 pages Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high |
From inside the book
Results 1-5 of 87
Page vii
... Collection scope IV . Voucher sampling , storage and retrieval V. Microcollection techniques VI . Data management and sample preparation VII . Extraction processes VIII . Removal of interfering substances IX . Test sample preparations ...
... Collection scope IV . Voucher sampling , storage and retrieval V. Microcollection techniques VI . Data management and sample preparation VII . Extraction processes VIII . Removal of interfering substances IX . Test sample preparations ...
Page 5
... collections in industry can contain hundreds of thousands of synthetic substances . Capacity permits their use in the ... collection purchases . Compound brokerage became a profitable support industry . The broker derives its supplies ...
... collections in industry can contain hundreds of thousands of synthetic substances . Capacity permits their use in the ... collection purchases . Compound brokerage became a profitable support industry . The broker derives its supplies ...
Page 6
... collection for a de novo HTS discovery program can easily cost several million dollars . Annual corporate budgets of $ 200,000 to $ 800,000 for synthetic compound acquisition are commonplace . These costs are amplified significantly by ...
... collection for a de novo HTS discovery program can easily cost several million dollars . Annual corporate budgets of $ 200,000 to $ 800,000 for synthetic compound acquisition are commonplace . These costs are amplified significantly by ...
Page 7
... collection techniques appear to be the answer . The marine world , which holds some of the most fascinating chemistry , encompasses plant , animal and microbial life forms . In chapter 4 of this section , Gregg Dietzman provides a ...
... collection techniques appear to be the answer . The marine world , which holds some of the most fascinating chemistry , encompasses plant , animal and microbial life forms . In chapter 4 of this section , Gregg Dietzman provides a ...
Page 10
... collection , of course , represents less than 1 % of what has been reported in the literature and an undefined , but ... collection program , for example , it would be preferable to develop the botanical sciences through education and ...
... collection , of course , represents less than 1 % of what has been reported in the literature and an undefined , but ... collection program , for example , it would be preferable to develop the botanical sciences through education and ...
Contents
Chemically Generated Screening Libraries | 145 |
Ill Assay Technologies and Detection Methods | 273 |
IV Automation and Robotics | 455 |
V Data Retrieval Handling and Integration | 547 |
VI Laboratory Design and Management | 623 |
Index | 669 |
Other editions - View all
High Throughput Screening: The Discovery of Bioactive Substances John P. Devlin Limited preview - 1997 |
Common terms and phrases
acid actinomycetes activity analysis antibody applications approach assay assay plate bar-code BIAcore binding assay biochemical biological diversity cells chelates Chem chemical diversity collection combinatorial chemistry combinatorial libraries companies components compounds concentration Contracting Party Convention cryptate database detection DMSO drug discovery enzyme evaluated example extracts Figure FlashPlate fluorescence format function gene handling high throughput screening HTRF HTS program identified immunoassays implementation incubation inhibition inhibitors instruments integrated interface labeled laboratory large numbers ligand luciferase marine natural products methods microbial microorganisms microplate molecular molecules neurotrophin operation optimization Oracle peptide performed pharmaceutical polyphenols protein protocol radioligand reaction reagents receptor reporter gene resin robotic system samples scintillation screening data screening program secondary metabolites signal solid phase solution specific streptavidin structure substrate synthesis synthetic Table target trkB workstations