High Throughput Screening: The Discovery of Bioactive SubstancesCRC Press, 1997 M05 6 - 704 pages Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high |
From inside the book
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Page vii
... Biological Diversity ( 1992 ) Appendix 3. Clinton Administration's Proposed Interpretation - 1994 Appendix 4. Internet Access to Natural Product Information Microcollection of Plants for Biochemical Profiling ... ... John P. Devlin I ...
... Biological Diversity ( 1992 ) Appendix 3. Clinton Administration's Proposed Interpretation - 1994 Appendix 4. Internet Access to Natural Product Information Microcollection of Plants for Biochemical Profiling ... ... John P. Devlin I ...
Page 3
The Discovery of Bioactive Substances John P. Devlin. 1 Chemical Diversity ... biological and biochemical events of the last decade at the cellular and ... Diversity and Genetic Equity: Synthetic and Naturally Derived Compounds I. Introduction.
The Discovery of Bioactive Substances John P. Devlin. 1 Chemical Diversity ... biological and biochemical events of the last decade at the cellular and ... Diversity and Genetic Equity: Synthetic and Naturally Derived Compounds I. Introduction.
Page 4
... DIVERSITY IS THE KEY In the late 80s , a quiet revolution began . The enormous market potential of the new targets ... biological assay would ultimately yield an active molecule . In a simple manner , the variables are represented as # HITS ...
... DIVERSITY IS THE KEY In the late 80s , a quiet revolution began . The enormous market potential of the new targets ... biological assay would ultimately yield an active molecule . In a simple manner , the variables are represented as # HITS ...
Page 5
... bio- evaluation of > 1,000,000 test substances annually . In larger companies , such programs form the core of lead ... diversity is assessed . The latter is without doubt the greatest source of structural and functional diversity but ...
... bio- evaluation of > 1,000,000 test substances annually . In larger companies , such programs form the core of lead ... diversity is assessed . The latter is without doubt the greatest source of structural and functional diversity but ...
Page 8
... Biological Diversity The Convention on Biological Diversity ( the " Convention " ) builds on the groundwork of earlier attempts at formulating an acceptable statement of international accountability in the use of natural resources ...
... Biological Diversity The Convention on Biological Diversity ( the " Convention " ) builds on the groundwork of earlier attempts at formulating an acceptable statement of international accountability in the use of natural resources ...
Contents
Chemically Generated Screening Libraries | 145 |
Ill Assay Technologies and Detection Methods | 273 |
IV Automation and Robotics | 455 |
V Data Retrieval Handling and Integration | 547 |
VI Laboratory Design and Management | 623 |
Index | 669 |
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High Throughput Screening: The Discovery of Bioactive Substances John P. Devlin Limited preview - 1997 |
Common terms and phrases
acid actinomycetes activity analysis antibody applications approach assay assay plate bar-code BIAcore binding assay biochemical biological diversity cells chelates Chem chemical diversity collection combinatorial chemistry combinatorial libraries companies components compounds concentration Contracting Party Convention cryptate database detection DMSO drug discovery enzyme evaluated example extracts Figure FlashPlate fluorescence format function gene handling high throughput screening HTRF HTS program identified immunoassays implementation incubation inhibition inhibitors instruments integrated interface labeled laboratory large numbers ligand luciferase marine natural products methods microbial microorganisms microplate molecular molecules neurotrophin operation optimization Oracle peptide performed pharmaceutical polyphenols protein protocol radioligand reaction reagents receptor reporter gene resin robotic system samples scintillation screening data screening program secondary metabolites signal solid phase solution specific streptavidin structure substrate synthesis synthetic Table target trkB workstations