High Throughput Screening: The Discovery of Bioactive SubstancesCRC Press, 1997 M05 6 - 704 pages Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high |
From inside the book
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Page iv
... biochemistry as an important partner in discovery within industrial programs . The new molecular focus promised significant advancement in the understanding of disease processes and new modes of therapy , but was limited seriously by ...
... biochemistry as an important partner in discovery within industrial programs . The new molecular focus promised significant advancement in the understanding of disease processes and new modes of therapy , but was limited seriously by ...
Page vii
... Biochemical Profiling ... ... John P. Devlin I. Introduction II . Botanical and chemical diversity III . Collection scope IV . Voucher sampling , storage and retrieval V. Microcollection techniques VI . Data management and sample ...
... Biochemical Profiling ... ... John P. Devlin I. Introduction II . Botanical and chemical diversity III . Collection scope IV . Voucher sampling , storage and retrieval V. Microcollection techniques VI . Data management and sample ...
Page xxi
... Biochemical Pharmacology , Allelix Biopharmaceuticals Inc. , 6850 Goreway Drive , Mississauga , Ontario L4V 1V7 ... Biochemistry xxi Contributors.
... Biochemical Pharmacology , Allelix Biopharmaceuticals Inc. , 6850 Goreway Drive , Mississauga , Ontario L4V 1V7 ... Biochemistry xxi Contributors.
Page xxii
... Biochemistry , 5377 Hilltop Crescent , Oakland , California , 94618 , U.S.A. Simon Ng , NEN Life Sciences / E . I. duPont de Nemours , 549 Albany Street , Boston , Massachusetts , 02118 , U.S.A. John M. Ostresh , Torrey Pines Inst . for ...
... Biochemistry , 5377 Hilltop Crescent , Oakland , California , 94618 , U.S.A. Simon Ng , NEN Life Sciences / E . I. duPont de Nemours , 549 Albany Street , Boston , Massachusetts , 02118 , U.S.A. John M. Ostresh , Torrey Pines Inst . for ...
Page xxiii
... Biochemical Pharmacology , Allelix Biopharmaceuticals Inc. , 6850 Goreway Drive , Mississauga , Ontario , L4V IV7 , Canada . Jana Williams , Molecular Devices Corporation , 1311 Orleans Drive , Sunnyvale , California , 94089 , U.S.A. ...
... Biochemical Pharmacology , Allelix Biopharmaceuticals Inc. , 6850 Goreway Drive , Mississauga , Ontario , L4V IV7 , Canada . Jana Williams , Molecular Devices Corporation , 1311 Orleans Drive , Sunnyvale , California , 94089 , U.S.A. ...
Contents
Chemically Generated Screening Libraries | 145 |
Ill Assay Technologies and Detection Methods | 273 |
IV Automation and Robotics | 455 |
V Data Retrieval Handling and Integration | 547 |
VI Laboratory Design and Management | 623 |
Index | 669 |
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High Throughput Screening: The Discovery of Bioactive Substances John P. Devlin Limited preview - 1997 |
Common terms and phrases
acid actinomycetes activity analysis antibody applications approach assay assay plate bar-code BIAcore binding assay biochemical biological diversity cells chelates Chem chemical diversity collection combinatorial chemistry combinatorial libraries companies components compounds concentration Contracting Party Convention cryptate database detection DMSO drug discovery enzyme evaluated example extracts Figure FlashPlate fluorescence format function gene handling high throughput screening HTRF HTS program identified immunoassays implementation incubation inhibition inhibitors instruments integrated interface labeled laboratory large numbers ligand luciferase marine natural products methods microbial microorganisms microplate molecular molecules neurotrophin operation optimization Oracle peptide performed pharmaceutical polyphenols protein protocol radioligand reaction reagents receptor reporter gene resin robotic system samples scintillation screening data screening program secondary metabolites signal solid phase solution specific streptavidin structure substrate synthesis synthetic Table target trkB workstations