High Throughput Screening: The Discovery of Bioactive SubstancesCRC Press, 1997 M05 6 - 704 pages Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high |
From inside the book
Results 1-5 of 77
Page v
... analysis with the accompanying increased risk of error . As these systems expanded into the evaluation of hundreds of compounds per week in multiple assays , efficiency in data management became the limiting factor . Scheduling , data ...
... analysis with the accompanying increased risk of error . As these systems expanded into the evaluation of hundreds of compounds per week in multiple assays , efficiency in data management became the limiting factor . Scheduling , data ...
Page xi
... II . The potential of fluorescence polarization III . Theory of fluorescence polarization IV . Instrumentation V. High Throughput Screening and FP 345 361 377 389 VI . Assay characteristics VII . Data analysis VIII . xi Contents.
... II . The potential of fluorescence polarization III . Theory of fluorescence polarization IV . Instrumentation V. High Throughput Screening and FP 345 361 377 389 VI . Assay characteristics VII . Data analysis VIII . xi Contents.
Page 3
... analysis . For the most part , companies relied upon the chemist's skills in synthesis and the pharmacologist's observational abilities to find the developmental candidate or “ lead ” that would yield a “ new and improved " therapeutic ...
... analysis . For the most part , companies relied upon the chemist's skills in synthesis and the pharmacologist's observational abilities to find the developmental candidate or “ lead ” that would yield a “ new and improved " therapeutic ...
Page 18
... analysis software , is applied in the cataloging of compounds from Chembridge's extensive compound libraries and the marketing of the same in catalog formats . Compounds are provided in 96 - well plate format through contract with ...
... analysis software , is applied in the cataloging of compounds from Chembridge's extensive compound libraries and the marketing of the same in catalog formats . Compounds are provided in 96 - well plate format through contract with ...
Page 20
... analysis and processing . Chemical partitioning is conducted to remove interfering constituents such as lipids , polyphenols , tannins , and complexed biopolymers . In association with MicroSource Discovery Systems , Inc. , these ...
... analysis and processing . Chemical partitioning is conducted to remove interfering constituents such as lipids , polyphenols , tannins , and complexed biopolymers . In association with MicroSource Discovery Systems , Inc. , these ...
Contents
Chemically Generated Screening Libraries | 145 |
Ill Assay Technologies and Detection Methods | 273 |
IV Automation and Robotics | 455 |
V Data Retrieval Handling and Integration | 547 |
VI Laboratory Design and Management | 623 |
Index | 669 |
Other editions - View all
High Throughput Screening: The Discovery of Bioactive Substances John P. Devlin Limited preview - 1997 |
Common terms and phrases
acid actinomycetes activity analysis antibody applications approach assay assay plate bar-code BIAcore binding assay biochemical biological diversity cells chelates Chem chemical diversity collection combinatorial chemistry combinatorial libraries companies components compounds concentration Contracting Party Convention cryptate database detection DMSO drug discovery enzyme evaluated example extracts Figure FlashPlate fluorescence format function gene handling high throughput screening HTRF HTS program identified immunoassays implementation incubation inhibition inhibitors instruments integrated interface labeled laboratory large numbers ligand luciferase marine natural products methods microbial microorganisms microplate molecular molecules neurotrophin operation optimization Oracle peptide performed pharmaceutical polyphenols protein protocol radioligand reaction reagents receptor reporter gene resin robotic system samples scintillation screening data screening program secondary metabolites signal solid phase solution specific streptavidin structure substrate synthesis synthetic Table target trkB workstations