High Throughput Screening: The Discovery of Bioactive SubstancesCRC Press, 1997 M05 6 - 704 pages Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high |
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Page 3
... activity modes was most often serendipitous and rarely through deductive analysis . For the most part , companies ... activities required legions of chemists and development scientists , and tedious and expensive time lines to the clinic ...
... activity modes was most often serendipitous and rarely through deductive analysis . For the most part , companies ... activities required legions of chemists and development scientists , and tedious and expensive time lines to the clinic ...
Page 12
... activity . Similarly , the tropical diseases group screens chemotherapeutic agents in malaria and filariasis . The Working Group on Plant Chemistry ( chaired by K. Hostettmann , U. Lausanne , Switzerland ) , organizes workshops on ...
... activity . Similarly , the tropical diseases group screens chemotherapeutic agents in malaria and filariasis . The Working Group on Plant Chemistry ( chaired by K. Hostettmann , U. Lausanne , Switzerland ) , organizes workshops on ...
Page 21
... activity was found . Further supplies are the recipient's responsibility under the terms of NCI's Materials Transfer Agreement . NCI has now decided to increase access to the repository . Qualified groups may receive up to 500 spls ...
... activity was found . Further supplies are the recipient's responsibility under the terms of NCI's Materials Transfer Agreement . NCI has now decided to increase access to the repository . Qualified groups may receive up to 500 spls ...
Page 25
... activities , regardless of where their effects occur , carried out under its jurisdiction or control , within the area of its national jurisdiction or beyond the limits of national jurisdiction . Article 5. Cooperation Each Contracting ...
... activities , regardless of where their effects occur , carried out under its jurisdiction or control , within the area of its national jurisdiction or beyond the limits of national jurisdiction . Article 5. Cooperation Each Contracting ...
Page 43
... Activities : Article 15 ( 6 ) . The United States believes it is necessary to clarify certain ambiguous provisions in the Convention that call for participation in research activities . Article 15 ( 6 ) provides that Contracting Parties ...
... Activities : Article 15 ( 6 ) . The United States believes it is necessary to clarify certain ambiguous provisions in the Convention that call for participation in research activities . Article 15 ( 6 ) provides that Contracting Parties ...
Contents
Chemically Generated Screening Libraries | 145 |
Ill Assay Technologies and Detection Methods | 273 |
IV Automation and Robotics | 455 |
V Data Retrieval Handling and Integration | 547 |
VI Laboratory Design and Management | 623 |
Index | 669 |
Other editions - View all
High Throughput Screening: The Discovery of Bioactive Substances John P. Devlin Limited preview - 1997 |
Common terms and phrases
acid actinomycetes activity analysis antibody applications approach assay assay plate bar-code BIAcore binding assay biochemical biological diversity cells chelates Chem chemical diversity collection combinatorial chemistry combinatorial libraries companies components compounds concentration Contracting Party Convention cryptate database detection DMSO drug discovery enzyme evaluated example extracts Figure FlashPlate fluorescence format function gene handling high throughput screening HTRF HTS program identified immunoassays implementation incubation inhibition inhibitors instruments integrated interface labeled laboratory large numbers ligand luciferase marine natural products methods microbial microorganisms microplate molecular molecules neurotrophin operation optimization Oracle peptide performed pharmaceutical polyphenols protein protocol radioligand reaction reagents receptor reporter gene resin robotic system samples scintillation screening data screening program secondary metabolites signal solid phase solution specific streptavidin structure substrate synthesis synthetic Table target trkB workstations