High Throughput Screening: The Discovery of Bioactive SubstancesCRC Press, 1997 M05 6 - 704 pages Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high |
From inside the book
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Page vi
... HTS discovery mode and provide a solid base for the development of HTS programs in the industrial environment ... program in the biological sciences . This text encompasses within its 40 chapters the contributions of 113 individuals each of ...
... HTS discovery mode and provide a solid base for the development of HTS programs in the industrial environment ... program in the biological sciences . This text encompasses within its 40 chapters the contributions of 113 individuals each of ...
Page xiii
... HTS III . The HTS process IV . Implementing an automation project V. Future prospects for automation in HTS 461 471 30. Bar - Code Technology and a Centralized Database : Key Components in a Radioligand Binding Program .... Elizabeth A ...
... HTS III . The HTS process IV . Implementing an automation project V. Future prospects for automation in HTS 461 471 30. Bar - Code Technology and a Centralized Database : Key Components in a Radioligand Binding Program .... Elizabeth A ...
Page xiv
... HTS Data Management Conclusion 525 549 551 583 37. Data Management and Tracking for Natural Product Programs ......... 599 Gregg R. Dietzman I. Introduction II . User requirements III . Implementing an ... HTS Program . Matthew Contents xiv.
... HTS Data Management Conclusion 525 549 551 583 37. Data Management and Tracking for Natural Product Programs ......... 599 Gregg R. Dietzman I. Introduction II . User requirements III . Implementing an ... HTS Program . Matthew Contents xiv.
Page xv
... HTS Program . Matthew A. Sills and Mark Crawford Introduction I. II . Program perspective III . Program logistics IV . Assays V. Samples VI . Resourcing VII . Management considerations 40. Establishing an HTS Program in a Start - Up ...
... HTS Program . Matthew A. Sills and Mark Crawford Introduction I. II . Program perspective III . Program logistics IV . Assays V. Samples VI . Resourcing VII . Management considerations 40. Establishing an HTS Program in a Start - Up ...
Page 4
... ( HTS ) was the result . HTS is based solely on statistics . The dedication of a screening program to one biochemical mechanism , for example , is less likely to succeed than a spectrum of assay targets in the therapeutic indication . The ...
... ( HTS ) was the result . HTS is based solely on statistics . The dedication of a screening program to one biochemical mechanism , for example , is less likely to succeed than a spectrum of assay targets in the therapeutic indication . The ...
Contents
Chemically Generated Screening Libraries | 145 |
Ill Assay Technologies and Detection Methods | 273 |
IV Automation and Robotics | 455 |
V Data Retrieval Handling and Integration | 547 |
VI Laboratory Design and Management | 623 |
Index | 669 |
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High Throughput Screening: The Discovery of Bioactive Substances John P. Devlin Limited preview - 1997 |
Common terms and phrases
acid actinomycetes activity analysis antibody applications approach assay assay plate bar-code BIAcore binding assay biochemical biological diversity cells chelates Chem chemical diversity collection combinatorial chemistry combinatorial libraries companies components compounds concentration Contracting Party Convention cryptate database detection DMSO drug discovery enzyme evaluated example extracts Figure FlashPlate fluorescence format function gene handling high throughput screening HTRF HTS program identified immunoassays implementation incubation inhibition inhibitors instruments integrated interface labeled laboratory large numbers ligand luciferase marine natural products methods microbial microorganisms microplate molecular molecules neurotrophin operation optimization Oracle peptide performed pharmaceutical polyphenols protein protocol radioligand reaction reagents receptor reporter gene resin robotic system samples scintillation screening data screening program secondary metabolites signal solid phase solution specific streptavidin structure substrate synthesis synthetic Table target trkB workstations