Psychopharmacology and Psychobiology of Ethnicity

Front Cover
American Psychiatric Pub, 1993 - 276 pages

Until several decades ago, few studies were conducted on the differences among individual responses to pharmacologic agents. Then, in the 1950s and 1960s, enzyme induction was discovered, and it became apparent that the intake of certain foods or drugs could adaptively modify drug metabolism and, therefore, drug response. Now researchers are beginning to realize how both adaptive and genetic forces may cause pharmacological distinctions among human populations once separated by distance or geographical boundaries.

Psychopharmacology and Psychobiology of Ethnicity provides a unique overview of how ethnically defined populations respond to psychoactive drugs. Its renowned contributors review and summarize our current knowledge of ethnic differences and similarities among patients in response to psychotropic drugs.

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Contents

Introduction Psychopharmacology Psychobiology and Ethnicity
3
Overview The Interface Between Psychobiology and Ethnicity
11
Nonbiological Issues Affecting Psychopharmacotherapy Cultural Considerations
37
Ethnicity and Psychopharmacology
59
Ethnicity and the Pharmacology of Tricyclic Antidepressants
61
Ethnicity and Differential Responses to Benzodiazepines
91
Interethnic Variation in Response to Lithium Therapy Among AfricanAmerican and AsianAmerican Populations
107
Influence of Ethnicity on Reduced Haloperidol Concentrations in Blood
123
Tardive Dyskinesia CrossCultural Perspectives
153
Genetic Polymorphisms of Alcohol Metabolizing Enzymes Related to Alcohol Sensitivity and Alcoholic Diseases
169
Ethnicity and Psychobiology
185
Ethnicity and Biological Markers
187
Biopsychosocial Perspective on Depression in AfricanAmericans
201
Clinical and Epidemiologic Studies of Dementias CrossEthnic Perspectives
223
Afterword
253
Index
257

Haloperidol and Reduced Haloperidol Plasma Concentrations in Different Ethnic Populations and Interindividual Variabilities in Haloperidol Metabol...
133

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About the author (1993)

Keh-Ming Lin, M.D., M.P.H., is Associate Professor of Psychiatry at the UCLA Department of Psychiatry and Research Center on the Psychobiology of Ethnicity, Harbor-UCLA Medical Center, Research and Education Institute, Inc., in Torrance, California.

Russell E. Poland, Ph.D., is a Research Pharmacologist at the UCLA Department of Psychiatry and Research Center on the Psychobiology of Ethnicity, Harbor-UCLA Medical Center, Research and Education Institute, Inc. in Torrance, California.

Gayle Nakasaki, M.S.W., is Assistant Director of the Research Center on the Psychobiology of Ethnicity at Harbor-UCLA Research and Education Institute, Inc., in Torrance, California.

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