Streptococcal Infections: Clinical Aspects, Microbiology, and Molecular Pathogenesis

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Dennis L. Stevens, Edward L. Kaplan
Oxford University Press, 2000 - 449 pages
Streptococcal Infections: Clinical Aspects, Microbiology, and Molecular Pathogenesis
offers an in-depth examination of the spectrum of hemolytic streptococcal infections and their complications. Additionally, the volume incorporates and discusses aspects of pneumococcal, entrococcal, and oral streptococcal disease. The recent resurgence of rheumatic fever, concomitant outbreaks of severe systemic group A streptococcal infections (often accompanied by toxic shock), an increasing incidence of multiple antibiotic resistance among streptococcal species, and an intensified effort to develop effective streptococcal vaccines have brought renewed attention to the continuing role of streptococci for causing significant medical and public health problems in both industrialized and developing countries.
Addressing clinical and epidemiological aspects, and microbiological and other approaches of the research scientist, this volume is the first to comprehensively address these clinically important organisms in many years. The contributors are internationally recognized for their expertise, making this book invaluable for infectious disease physicians, (internists, pediatricians, and family physicians, microbiologists, epidemiologists, and basic scientists with an interest in streptococcal infections and their complications.

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Contents

History of Hemolytic Streptococci and Associated Diseases
1
Group A BetaHemolytic Streptococci Virulence Factors Pathogenesis and Spectrum of Clinical Infections
19
Group A Streptococcal Genetics and Virulence
37
Exotoxins of Streptococcus pyogenes
57
Streptococcal Pharyngitis
76
Rheumatic Fever Pathogenesis
102
Rheumatic Fever
133
Streptococcal Pyoderma
144
Group C and G Streptococci
238
Nonhemolytic Streptococci
255
Laboratory Evaluation of Streptococci
266
Enterococcal Infections
280
Streptococcus pneumoniae Infections
302
Oral Streptococci in Health and Disease
333
Protection Against Group A Streptococcal Infection
371
Multivalent Group A Streptococcal Vaccines
390

Acute Poststreptococcal Glomerulonephritis
152
LifeThreatening Streptococcal Infections Scarlet Fever Necrotizing Fasciitis Myositis Bacteremia and Streptococcal Toxic Shock Syndrome
163
Molecular Pathogenesis of Group B Streptococcal Disease in Newborns
180
Group B Streptococcal Infections
222
Group B Streptococcal Vaccines
402
Vaccine Strategies for Streptococcus pneumoniae
419
Index
435
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