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Page 110
... and Drug Administration Guidelines for Animal Toxicity Studies Requirements for subacute or chronic toxicity studies Category Duration of human administration Study phase Oral or parenteral Several days As long as 2 weeks As long as ...
... and Drug Administration Guidelines for Animal Toxicity Studies Requirements for subacute or chronic toxicity studies Category Duration of human administration Study phase Oral or parenteral Several days As long as 2 weeks As long as ...
Page 131
tered intravenously with 103 cells , resulting in a mean survival rats fed 0.2 % had progressive lesions beginning with mild time of 14 to 21 days ( 31 ) . hyperplasia at 2 to 4 weeks , to moderate hyperplasia at 6 to 8 The Murphy ...
tered intravenously with 103 cells , resulting in a mean survival rats fed 0.2 % had progressive lesions beginning with mild time of 14 to 21 days ( 31 ) . hyperplasia at 2 to 4 weeks , to moderate hyperplasia at 6 to 8 The Murphy ...
Page 169
( 123 ) reported an increased heart weight to body weight ratio as early as 3-4 weeks of age prior to the development of increased blood pressure , Kawamura et al . ( 65 ) did not find increased heart weight until 13 weeks of age .
( 123 ) reported an increased heart weight to body weight ratio as early as 3-4 weeks of age prior to the development of increased blood pressure , Kawamura et al . ( 65 ) did not find increased heart weight until 13 weeks of age .
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Contents
Identification Methods | 4 |
Specimen Collection | 5 |
Substance Administration | 19 |
Copyright | |
14 other sections not shown
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Common terms and phrases
Acad activity addition administration adult agents antigens appear Arch artery Biol blood body cage Cancer Cancer Res carcinogenesis carcinogens carcinomas caries cells changes chemical collection compared compounds described determined diet disease dose drug duct effects embryo evaluation experimental experiments exposure factors female function genetic germfree gland growth heart human hypertension incidence increased induced infection isolated laboratory animals laboratory rat lesions liver lymphocytes male material method mg/kg mice months normal observed obtained occur oral organ Pathology period Physiol placed placenta potential present Press pressure Proc procedure produced Reference reported response selected species specific spontaneous strain studies Table technique teratogenic tion tissue toxicity transplantable tumors types usually various volume weeks weight Wistar York
Bibliographic information
| Title | The Laboratory Rat: Research applications Volume 2 of American College of Laboratory Animal Medicine series, American College of Laboratory Animal Medicine Volume 2 of The Laboratory Rat, Steven H. Weisbroth The Laboratory Rat: Research Applications V. II, James Russell Lindsey |
| Editors | Henry J. Baker, James Russell Lindsey, Steven H. Weisbroth |
| Edition | illustrated |
| Publisher | Academic Press, 1979 |
| Original from | the University of Michigan |
| Digitized | 16 Jul 2008 |
| ISBN | 0120749025, 9780120749027 |
| Length | 276 pages |
| Export Citation | BiBTeX EndNote RefMan |