The Laboratory Rat: Research applicationsHenry J. Baker, James Russell Lindsey, Steven H. Weisbroth Academic Press, 1979 - 276 pages |
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Page 105
... studies involving drug distribution within the body and mechanisms of drug action and toxicity . Laboratory rats are commonly used as the rodent species of choice , along with the mongrel or Beagle dog as the nonrodent species , to ...
... studies involving drug distribution within the body and mechanisms of drug action and toxicity . Laboratory rats are commonly used as the rodent species of choice , along with the mongrel or Beagle dog as the nonrodent species , to ...
Page 109
... studies ( phase I ) Study - rats Reproduction and fertility ) Segment II teratology study Mechanism of action Studies in man Fig . 1. Key research and development activities in the pharmacologic and toxicologic testing of a typical new ...
... studies ( phase I ) Study - rats Reproduction and fertility ) Segment II teratology study Mechanism of action Studies in man Fig . 1. Key research and development activities in the pharmacologic and toxicologic testing of a typical new ...
Page 111
... studies in experimental animals . In some in- stances , studies involving several generations are necessary to provide information on potentially long - term effects in hu- mans . Data from these studies also provide useful insight into ...
... studies in experimental animals . In some in- stances , studies involving several generations are necessary to provide information on potentially long - term effects in hu- mans . Data from these studies also provide useful insight into ...
Contents
Substance Administration | 19 |
THE LABORATORY RAT VOL II Copyright 1980 by Academic Press | 43 |
List of Contributors | 75 |
Copyright | |
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Academic Press adult agents Anat anesthesia anesthetic animal model antibody antigens Arch artery biochemical Biol blastocyst blood pressure BN/Bi body weight cage Cancer Inst Cancer Res carcinogenesis carcinogens carcinomas cardiac caries cavity cells chemical chronic Clin dental caries diet disease dose drug duct effects embryo enzyme euthanasia evaluation experimental exposure factors female genetic germfree germfree rats GF rats gland gnotobiotic heart histocompatibility human hypertension IARC IARC Sci immune immunoglobulin Immunol implantation inbred induced infection intravenous isolator laboratory animals laboratory rat lesions leukemia liver lymph lymphocytes male malformations mammary metabolism method mg/kg molars mouse myocardium myocytes N. Y. Acad Natl neoplasms normal oral Pathol Pathology Physiol placenta Proc procedure protein response rodents specific spontaneous Sprague-Dawley studies technique teratogenic Teratology thoracic duct tion tissue toxicity transplantable trypan blue tumors vitro WAG/Rij Wistar Wistar rats yolk sac