The Laboratory Rat: Research applicationsHenry J. Baker, James Russell Lindsey, Steven H. Weisbroth Academic Press, 1979 - 276 pages |
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Page 111
... effects in hu- mans . Data from these studies also provide useful insight into the design of human trials and can help to predict what effects might be expected in initial clinical studies in humans . Since rodent and nonrodent species ...
... effects in hu- mans . Data from these studies also provide useful insight into the design of human trials and can help to predict what effects might be expected in initial clinical studies in humans . Since rodent and nonrodent species ...
Page 114
... effects of high doses of the new drug , and in this way provide fundamental data for the design of more complex animal studies ( 39 ) . The simplest acute toxicity trial is an LD50 . This is a single dosing of five or six groups of 10 ...
... effects of high doses of the new drug , and in this way provide fundamental data for the design of more complex animal studies ( 39 ) . The simplest acute toxicity trial is an LD50 . This is a single dosing of five or six groups of 10 ...
Page 115
... effects of the test chemical on the male and female repro- ductive systems . At the same time , the drug is studied for any potentially harmful effects on the developing fetus when the dam is dosed during a specific period of pregnancy ...
... effects of the test chemical on the male and female repro- ductive systems . At the same time , the drug is studied for any potentially harmful effects on the developing fetus when the dam is dosed during a specific period of pregnancy ...
Contents
Substance Administration | 19 |
THE LABORATORY RAT VOL II Copyright 1980 by Academic Press | 43 |
List of Contributors | 75 |
Copyright | |
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Academic Press adult agents Anat anesthesia anesthetic animal model antibody antigens Arch artery biochemical Biol blastocyst blood pressure BN/Bi body weight cage Cancer Inst Cancer Res carcinogenesis carcinogens carcinomas cardiac caries cavity cells chemical chronic Clin dental caries diet disease dose drug duct effects embryo enzyme euthanasia evaluation experimental exposure factors female genetic germfree germfree rats GF rats gland gnotobiotic heart histocompatibility human hypertension IARC IARC Sci immune immunoglobulin Immunol implantation inbred induced infection intravenous isolator laboratory animals laboratory rat lesions leukemia liver lymph lymphocytes male malformations mammary metabolism method mg/kg molars mouse myocardium myocytes N. Y. Acad Natl neoplasms normal oral Pathol Pathology Physiol placenta Proc procedure protein response rodents specific spontaneous Sprague-Dawley studies technique teratogenic Teratology thoracic duct tion tissue toxicity transplantable trypan blue tumors vitro WAG/Rij Wistar Wistar rats yolk sac