The Laboratory Rat: Research applicationsHenry J. Baker, James Russell Lindsey, Steven H. Weisbroth Academic Press, 1979 - 276 pages |
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Page 109
... drug . Table II Food and Drug Administration Guidelines for Animal Toxicity. more than 10 million dollars to develop a single new drug . As an average , more than 5000 chemicals are synthesized and investigated in order to finally ...
... drug . Table II Food and Drug Administration Guidelines for Animal Toxicity. more than 10 million dollars to develop a single new drug . As an average , more than 5000 chemicals are synthesized and investigated in order to finally ...
Page 115
... drug when administered over an extended period of time compatible with that for which the drug might be used when commercially available . These tests are specifically re- quired for drugs which will be given to human patients for long ...
... drug when administered over an extended period of time compatible with that for which the drug might be used when commercially available . These tests are specifically re- quired for drugs which will be given to human patients for long ...
Page 118
... drugs from the gastrointestinal tract . In " The Physiological Equivalence of Drug Dosing Forms , " Food and Drug Directorate , Ottawa , Canada . 7. Brodie , B. B. , and Reid , W. D. ( 1969 ) . Is man a unique animal in response to drugs ...
... drugs from the gastrointestinal tract . In " The Physiological Equivalence of Drug Dosing Forms , " Food and Drug Directorate , Ottawa , Canada . 7. Brodie , B. B. , and Reid , W. D. ( 1969 ) . Is man a unique animal in response to drugs ...
Contents
Substance Administration | 19 |
THE LABORATORY RAT VOL II Copyright 1980 by Academic Press | 43 |
List of Contributors | 75 |
Copyright | |
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Academic Press adult agents Anat anesthesia anesthetic animal model antibody antigens Arch artery biochemical Biol blastocyst blood pressure BN/Bi body weight cage Cancer Inst Cancer Res carcinogenesis carcinogens carcinomas cardiac caries cavity cells chemical chronic Clin dental caries diet disease dose drug duct effects embryo enzyme euthanasia evaluation experimental exposure factors female genetic germfree germfree rats GF rats gland gnotobiotic heart histocompatibility human hypertension IARC IARC Sci immune immunoglobulin Immunol implantation inbred induced infection intravenous isolator laboratory animals laboratory rat lesions leukemia liver lymph lymphocytes male malformations mammary metabolism method mg/kg molars mouse myocardium myocytes N. Y. Acad Natl neoplasms normal oral Pathol Pathology Physiol placenta Proc procedure protein response rodents specific spontaneous Sprague-Dawley studies technique teratogenic Teratology thoracic duct tion tissue toxicity transplantable trypan blue tumors vitro WAG/Rij Wistar Wistar rats yolk sac