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Page 112
Type of study Number of animals used Acute studies LD 50 , single dose , 14 - day observation 50-60 50-60 50-60 6-8 5 / sex / level , 3 dose levels Dose range , 14 days consecutive dosing 2 / sex / level , 2-3 dose levels Subchronic ...
Type of study Number of animals used Acute studies LD 50 , single dose , 14 - day observation 50-60 50-60 50-60 6-8 5 / sex / level , 3 dose levels Dose range , 14 days consecutive dosing 2 / sex / level , 2-3 dose levels Subchronic ...
Page 114
Table IV ( Continued ) dosage group is determined . If one of the dosage groups has an exact 50 % mortality , the LD50 is readily approximated . In most mg of the free base . In the report , the dose will be stated as the base ( or acid ) ...
Table IV ( Continued ) dosage group is determined . If one of the dosage groups has an exact 50 % mortality , the LD50 is readily approximated . In most mg of the free base . In the report , the dose will be stated as the base ( or acid ) ...
Page 265
Table I ( Continued ) Drug Classification Dosage Comment Reference Mustard Miscellaneous irritant 43 ... 3x / week Dose prevented body weight gain 0.02 % of feed Dose prevented body weight gain 8 mg / kg po 3x / week Dose prevented body ...
Table I ( Continued ) Drug Classification Dosage Comment Reference Mustard Miscellaneous irritant 43 ... 3x / week Dose prevented body weight gain 0.02 % of feed Dose prevented body weight gain 8 mg / kg po 3x / week Dose prevented body ...
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Contents
Identification Methods | 4 |
Specimen Collection | 5 |
Substance Administration | 19 |
Copyright | |
14 other sections not shown
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Acad activity addition administration adult agents antigens appear Arch artery Biol blood body cage Cancer Cancer Res carcinogenesis carcinogens carcinomas caries cells changes chemical collection compared compounds described determined diet disease dose drug duct effects embryo evaluation experimental experiments exposure factors female function genetic germfree gland growth heart human hypertension incidence increased induced infection isolated laboratory animals laboratory rat lesions liver lymphocytes male material method mg/kg mice months normal observed obtained occur oral organ Pathology period Physiol placed placenta potential present Press pressure Proc procedure produced Reference reported response selected species specific spontaneous strain studies Table technique teratogenic tion tissue toxicity transplantable tumors types usually various volume weeks weight Wistar York