The Laboratory Rat: Research applicationsHenry J. Baker, James Russell Lindsey, Steven H. Weisbroth Academic Press, 1979 - 276 pages |
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Page 109
... determine stability , and purity of the chem- ical . 4. Conduct pharmacological screening tests for efficacy using laboratory animal models . 5. Perform metabolism studies to determine the absorption , distribution , and elimination of ...
... determine stability , and purity of the chem- ical . 4. Conduct pharmacological screening tests for efficacy using laboratory animal models . 5. Perform metabolism studies to determine the absorption , distribution , and elimination of ...
Page 114
... determine the dose which kills 50 % of a representative rat population . The LD50 studies may also be conducted using other routes of administration , with oral dosing and in- traperitoneal injection being commonly used . A specific ...
... determine the dose which kills 50 % of a representative rat population . The LD50 studies may also be conducted using other routes of administration , with oral dosing and in- traperitoneal injection being commonly used . A specific ...
Page 214
... determine the ability of a recipient to tolerate or reject tissue grafts from a donor . If the donor and recipient ... determine the inheritance pattern and expression of the genes that control the phenotypical traits P1 and P2 . Using ...
... determine the ability of a recipient to tolerate or reject tissue grafts from a donor . If the donor and recipient ... determine the inheritance pattern and expression of the genes that control the phenotypical traits P1 and P2 . Using ...
Contents
Substance Administration | 19 |
THE LABORATORY RAT VOL II Copyright 1980 by Academic Press | 43 |
List of Contributors | 75 |
Copyright | |
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Academic Press adult agents Anat anesthesia anesthetic animal model antibody antigens Arch artery biochemical Biol blastocyst blood pressure BN/Bi body weight cage Cancer Inst Cancer Res carcinogenesis carcinogens carcinomas cardiac caries cavity cells chemical chronic Clin dental caries diet disease dose drug duct effects embryo enzyme euthanasia evaluation experimental exposure factors female genetic germfree germfree rats GF rats gland gnotobiotic heart histocompatibility human hypertension IARC IARC Sci immune immunoglobulin Immunol implantation inbred induced infection intravenous isolator laboratory animals laboratory rat lesions leukemia liver lymph lymphocytes male malformations mammary metabolism method mg/kg molars mouse myocardium myocytes N. Y. Acad Natl neoplasms normal oral Pathol Pathology Physiol placenta Proc procedure protein response rodents specific spontaneous Sprague-Dawley studies technique teratogenic Teratology thoracic duct tion tissue toxicity transplantable trypan blue tumors vitro WAG/Rij Wistar Wistar rats yolk sac