Antihypertensive DrugsCRC Press, 1997 M09 5 - 704 pages Twenty US and European contributors from academia and pharmaceutical companies present a tripartite discussion of the short but impressive history of drug treatment of essential hypertension, focusing on: medicinal chemistry, pharmacology, and the clinical picture. Each successive generation of drugs (e.g. beta-blockers, calcium antagonists, and ACE-inhibitors) permits more precise tailoring to individual patient needs, as well as further elucidating the pathophysiology of the disease. Those interested in integrative medicine will appreciate the paper on treating hypertension in the elderly and diabetics, which refers to non-drug lifestyle approaches to lowering blood pressure. Annotation copyrighted by Book News, Inc., Portland, OR |
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Contents
Neutral Endopeptidase and AngiotensinConverting Enzyme | 113 |
Endothelin Blockade and Hypertension | 213 |
1 | 225 |
Adrenoceptors | 281 |
Vasodilators and Calcium Antagonists | 313 |
T Godfraind | 368 |
in Hypertension | 377 |
4 | 386 |
Common terms and phrases
ACE inhibitors agents agonist amino acids analogs AngII angiotensin II angiotensin II antagonists angiotensin II receptor antihypertensive antihypertensive drugs aorta arteries AT₁ AT2 receptors beta-blockers binding affinity bioavailability Bioorg Med Chem blockade blockers blood pressure bosentan Ca2+ calcium antagonists calcium channels captopril cardiac output Cardiovasc Pharmacol cardiovascular cells Chem Lett Clin clinical clonidine CO₂H compounds converting enzyme coronary decrease derivatives dihydropyridine dipeptides diuretics dose duration of action enzyme inhibitors essential hypertension Figure Fournié-Zaluski Godfraind heart failure hemodynamic human hypertensive patients hypotensive imidazole increase inhibition lacidipine levels losartan membranes mg/kg natriuretic peptide NEP inhibitors neutral endopeptidase nifedipine nisoldipine nonpeptide angiotensin orally active peripheral pharmacological phosphoramidon potent prazosin pressor response rabbit aorta receptor antagonists receptor subtypes reduced renal renin renin inhibitors renin-angiotensin system ring selective sodium studies synthesis tetrazole therapy thiorphan Timmermans tissue trials urapidil vascular smooth muscle vasodilator verapamil vitro vivo Zwieten
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