Atypical Parkinsonian Disorders: Clinical and Research AspectsIrene Litvan Springer Science & Business Media, 2007 M10 27 - 512 pages A comprehensive review of what is known not only about the cause and treatment of atypical parksonian disorders, but also the issues that clinicians, researchers, patients, and caregivers face in dealing with them. The authors cover the basic science (history, epidemiology, genetics, pathology, nosology, computer modeling, and animal models), detailed clinical and laboratory assessments, and available diagnostic tools, including neuropsychiatric, neurologic, neuropsychologic, speech, electrophysiologic, and imaging evaluations. Current and future therapeutic approaches are also detailed, along with extensive discussions about future research directions. |
Contents
| 11 | |
| 22 | |
| 33 | |
Animal Models of Tauopathies | 65 |
Neurodegenerative Synucleinopathies | 77 |
Computer Modeling in Basal Ganglia Disorders | 95 |
Neuropathology and Nosology | 111 |
Implications for Nosology | 139 |
Progressive Supranuclear Palsy | 287 |
The Syndrome and the Disease | 309 |
Multiple System Atrophy | 335 |
Clinical Diagnosis of Dementia With Lewy Bodies | 361 |
Clinical Diagnosis of Familial Atypical Parkinsonian Disorders | 375 |
Clinical Diagnosis of Vascular Parkinsonism | 393 |
Role of Electrophysiology in Diagnosis and Research | 409 |
Role of CT and MRI in Diagnosis and Research | 431 |
Role of Neuropsychiatric Assessment in Diagnosis and Research | 163 |
Added Value of the Neuropsychological Evaluation | 185 |
Role of Praxis in Diagnosis and Assessment | 197 |
Role of Visuospatial Cognition Assessment in the Diagnosis and Research | 213 |
Role of Ocular Motor Assessment in Diagnosis and Research | 235 |
Characterizing and Assessing Speech and Language Disturbances | 255 |
Quality of Life Assessment in Atypical Parkinsonian Disorders | 277 |
Role of Functional Magnetic Neuroimaging in Diagnosis and Research | 451 |
PET and SPECT Imaging in Atypical Parkinsonian Disorders | 459 |
Current and Future Therapeutic Approaches | 473 |
Rehabilitation of Patients With Atypical Parkinsonian Disorders | 485 |
Overview and Future Research | 495 |
Index | 503 |
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Common terms and phrases
abnormalities activity Alzheimer’s disease apraxia assessment associated atypical parkinsonian disorders basal ganglia behavior brain cause cell changes clinical cognitive common compared cortex cortical corticobasal degeneration criteria cytoplasmic deficits dementia dementia with Lewy depression described develop diagnosis differential disturbances dysfunction dystonia early effects et al examination findings frontal function gene genetic human imaging impairment improve increased involvement lesions levodopa Lewy bodies limb Litvan loss measures midbrain motor Mov Disord movement multiple system atrophy mutations neurites Neurol Neurol Neurosurg Psychiatry Neurology Neuropathol normal observed occur onset Parkinson’s disease parkinsonism pathology patients PD patients performance Pick’s disease postural present processes progressive supranuclear palsy protein reduced regions reported response result rigidity saccades severe signs specific speech substantia nigra suggested symptoms syndrome synuclein task tion treatment tremor usually visual