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NATIONAL COUNCIL TO COMBAT BLINDNESS, INC.
Grant-in-aid awards prior to 1953

Institution

Boston City Hospital...

New York Medical College, Flower and
Fifth Avenue Hospitals.
Northwestern University Medical College.

Nuffield Laboratory of Ophthalmology, the Eye Hospital, Oxford University, England.

University of Pennsylvania........

Retina Foundation, Massachusetts Eye and Ear Infirmary.

University Hospitals, University of Iowa (continuation).

New York University Post-Graduate Medical School.

New York Eye and Ear Infirmary.... University Hospitals, University of Iowa..

University of California Medical School. University of Pennsylvania (continuation). Government Hospital, Haifa, Israel.. Indiana University Medical School.....

New York Hospital, Cornell Medical Center.

New York Medical College, Flower and Fifth Avenue Hospitals (continuation). Retina Foundation, Massachusetts Eye and Ear Infirmary (continuation). University Hospitals, University of Iowa (continuation).

New York Eye and Ear Infirmary.
Wills Eye Hospital, Philadelphia................

New York Medical College, Flower and
Fifth Avenue Hospitals.
Stanford University School of Medicine...

University of Louisville School of Medicine.

New York Hospital, Cornell Medical Center.

Yale University School of Medicine......

New York Hospital, Cornell Medical Center.

Yale University School of Medicine....

Indiana University Medical Center..

Project title

Study into electrical responses of retina and brain in patients with amblyopia ex anopsia and suppression. Regional light sensitivity of the retina-technique and theory.

Quantitative measurements of ocular fluorescein fluorescence in normal and glaucomatous eyes. Investigation into the normal and abnormal structures of the vitreous humor by michrochemical and histochemical methods. Virus infections of ocular tissues grafted onto the choricallantoic membrane of the chick membrane.

Acid mucopolysaccharides in the vitreous body; their role in the composition of the vitreous body and their relationship to the proteins in the vitreous gel.

Electrical responses of retina and brain in patients with amblyopia ex anopsia and suppression. Attempts to grow the virus of inclusion conjunctivitus, follicular conjunctivitus, and folliculosis.

Investigation into the role of focal infection in the etiology of nonspecific ocular inflammation. Investigation into the incidence and basic cause of cataract, hemorrhages, and degenerative changes in the retina and optic nerve of alloxan diabetic animals.

Relationship of uveitis to bacterial allergy. Virus infections of ocular tissues grafted onto the choricallantoic membrane of the chick embryo. Investigation into factors affecting new vessel growth into the cornea.

Study into the mechanism of development of contralateral granulomatous uveitis from the use of horse serum in rabbits. Retinopathy in diabetes..

Regional light sensivity of the retina-technique and theory.

Electrical responses of retina and brain in patients with amblyopia ex anopsia and suppression. The possible role of hyperstrinism in the etiology of retrolental fibroplasia. Investigation of the intermediary reactions and the enzyme systems involved in the anaerobic glycosis of the lens.

Detection of plane polarized light by the human

eye.

Amount

$6,000

1,700

936

1,730

5,000

5,000

2,700

1,296

1,600

1, 200

1.200

2,500

2,500

1,500

750

466

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5,000

2,500

3,750

2,625

2,500

2, 445

2, 125

200

500

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Visual characteristics of macular and peripheral retina in amblyopia associated with convergent and divergent deviation.

Role of estrogenic and androgenic substances on the retinal vascular pattern in alloxan diabetic

rats.

Investigations into the efficacy of certain therapies in the treatment of retinitis pigmentosa and other night blinding diseases.

Study of application of ACTH in primary glau

coma.

Study into choroideremia...-----

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Grant-in-aid and fellowship awards for the fiscal year 1953-54

GRANTS-IN-AID

Investigators

1. Goodwin, M. Breinin, M, D.

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2. Hermann M. Burian, M. D. (continua- Department of Ophthalmoltion grant).

ogy, University Hospitals, Iowa City, Iowa.

3. T. S. Danowski, M. D., and Lawrence University of Pittsburgh,
Greenman, M. D.
School of Medicine.

2,500

Project title

Lay explanation

Neotetrazolium studies in the eye (de- Study of the physiology of the eye to determine under
hydrogenase tracing).

3,000 Continued studies in electroretino-
graphy.

950

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certain abnormal conditions problems relating to
glaucoma, cataracts, and corneal transplantation.
Study of the retinal function by means of electric
responses in relation to defective vision in children
with crossed eyes and in certain diseases of the
retina in children and adults.com
The investigator plans to conduct a study into the
factors which affect the development of a certain
type of cataract by inducing the condition in experi-
mental animals through diets high in galactose.
These studies should help to bring information
about the formation of certain types of cataracts
found in infants and growing children.

Study into length and size of the human eye. This
investigation may provide valuable information
with regard to myopia and concerning eyeballs
which develop retinal detachment. It may also
provide information which may give assistance in
determining the need for eyeball shortening in
retinal detachment.
A continued study into the metabolism of the lens to
further clarify method of lens development and
cataract formation.
Study into a widespread parasitic disease in domestic
animals. This disease called toxoplasmosis can be
transmitted from mother to unborn child. This
study may provide the answer to how parents
acquire this type of infection which can produce
encephalitis as well as destructive processes involv-
ing the retina.

This study is concerned with determining more
effective techniques in preventing and healing of
scars in the cornea of the eye.

A study concerned with the hereditary factors in
certain eye diseases, such as abnormality of the
lens, glaucoma and other congenital abnormalities.
This investigation is being conducted by a famous
Turkish eye specialist and is concerned with a
study of a virus which produces a serious blinding
eye disease in which the major problem is a uveitis
of both eyes. This is a disease which also produces
disturbances of the urinary genital system. This
project may prove to be one of the most important
contributions in virology.

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3,000

Tulane University Medical
School.

400

Cerrahpasa Hospital, Istan-
bul, Turkey.

2,000

Grant-in-aid and fellowship awards for the fiscal year 1953-54-Continued

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Study to improve the safety of X-ray treatment of the eye.

Study into certain structures of the human eye, par-
ticularly the rods and cones, the cells which have
to do with vision in the retina. Investigator also
plans to study certain photo sensitive structures
in lower organisms and plant cells which are capa-
ble of changing light energy to chemical energy
and nerve impulses. This may shed light on
understanding the function of vision and its retinal
diseases.

The blood serum reaction in patients with sarcoidosis
upon certain blood serum reaction for tuberculosis
and other conditions.

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1 This fellow is being financed by the Michael Tenzer Memorial Fund of the National Council To Combat Blindness.

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The CHAIRMAN. We thank you. Dr. Gordon, I feel terribly embarrassed.

Miss WEISENFELD. Dr. Gordon has asked me to include in the record his statement.

The CHAIRMAN. It will be included in the record at this point. (The statement referred to is as follows:)

STATEMENT OF DAN M. GORDON, M. D., NEW YORK

QUALIFICATIONS

Graduate of the School of Medicine, University of Michigan, 1932.

Diplomate of the American College of Ophthalmology.

Fellow of the American College of Surgeons.

Fellow of the American Academy of Ophthalmology and Oto-Laryngology.

Fellow of Pan-American Ophthalomological Society.

Assistant Professor of Clinical Surgery (Ophthalmology) Cornell.

University Medical College.

Assistant, attending staff, New York Hospital.

Chairman of the medical board of the National Council to Combat Blindness.

Member of the American Medical Association and New York State and New York County Medical Societies.

Fellow of the American Medical Association.

Consultant to the Council on Pharmacy, American Medical Association.

A pioneer in the introduction of ACTH and cortisone into ophthalmology.
Authority on night-blinding diseases.

Member of the National Advisory Institute of Neurological Diseases and Blindness Council.

Author of various ophthalmological articles.

Special consultant in ophthalmology to the Surgeon General United States Public Health Service.

The organization of the average medical school eye department in this country has not been conducive to the conduction of a good eye research program, until recently. Since ophthalmology is primarily a clinical subject, most eye departments are headed by part-time clinicians, who (for the most part) are too busy with their private practices to devote much time to their departments or to research programs. Those who are and were desirous of carrying out intensive research projects on a large scale involving ophthalmologists, chemists, physicists and other allied technical skills were (and are) stymied by lack of funds. Most departments still lack adequate funds with which to carry out their necessary teaching programs; and depend upon part-time men who devote their time free. Postgraduate programs are virtually nonexistent in most medical school eye departments excepting for the training of their own immediate house staffs (interns and residents).

During the last decade or so there has been a gradual change in the organizational policies of many medical schools in the direction of building up the socalled minor specialties (eye, ear, nose and throat, dermatology, neurology, etc.) into major departments.

This has involved the gradual replacement (where funds could be found) of part time heads, etc., by full time men and the addition of other full time men; with the concommitant stimulation of subspecialization within the field of ophthalmology. This latter has meant that many well trained men are now devoting themselves to the study of various problems within the broad field of ophthalmology (such as diseases of one part of the eye, the various diseases involving the eye and the brain together, etc.) Since problems and fields tend to overlap this intense concentration on, what appear to be, very small areas within a broad field has actually meant that as one problem is solved, a key has automatically been furnished which may open the door to the solution of a related problem.

As a matter of fact there has been an awakening consciousness of the fact that the eye is part of the whole body and is involved in the ilnesses of the latter. A good example of this is diabetes, a general disease which is high in the list of causes of blindness. One of your own Members of Congress is blind as a result of diabetes. Another example is that the hormones ACTH and cortisone which were brought out for the relief of arthritis have proved more valuable in the treatment of certain blinding eye diseases. It is to the eternal credit of

Congress that the first funds which facilitated this great research program in all phases of medicine were appropriated by your body.

It is no secret that the medical schools have been hamstrung by lack of funds; and that this dearth has inevitably handicapped the smaller departments more than the larger ones. Since the eye departments are usually the smaller ones (numerically) in each medical school, they have suffered bitterly on this score. In many medical schools the eye department is a part of surgery, and dependent upon that department for funds for its very life. Since the surgical department never has sufficient funds for its own ends, it follows that the eye department suffers the consequences of that poverty. Since practically all research in the field of blindness is done in medical schools, it follows that the flames of progress depend upon outside funds for fuel. The amount of such moneys has been virtually negligible until the creation of the Institute of Neurological Diseases and Blindness. The speaker has had the privilege of being on the first council of

that institute.

The impact of this institute on the eye profession has been a deep one. Many eye departments which formerly have gone begging for funds and which have had difficulty in holding their staffs together (for want of funds with which to pay salaries, etc.) have suddenly sprung into full bloom as a result of this aid. The Retina Foundation in Boston is one of these. Western Reserve is another which has been built up by such funds. The University of Indiana is another. In fact many of the top eye departments in this country owe their high positions and excellent research programs to the funds supplied by this country. If that aid was suddenly withdrawn the wheels of eye research in this country would come to an almost virtual standstill in many institutions. The bulk of the present day work on inflammatory eye diseases which has saved so many thousands from blindness has been done by men financed by the institute. The brilliant work and new advances in retinal detachment surgery has received much of its financial support from Government funds. The beautiful work done at Manhattan Eye and Ear Hospital in the elucidation of certain previously unknown facts about the retina was done on your funds; as was the equally brilliant work at Western Reserve University on the electrical responses of the eye. The only important work on a new diagnostic tool, the pupilography camera, is being carried out with institute funds at Columbia University. I could similarly point out example after example of invaluable discoveries made solely because a far-seeing Congress has made funds available-limited though these may have been.

The investigation of eye disease is but a phase in a much broader problem. Once important discoveries have been made, these must become available to the afflicted public. It requires about 5 years for new treatments to percolate down through the masses. Methods of postgraduate education must be extended, provided, and stimulated. New teaching mechanisms must be devised for the more rapid dissemination of knowledge. Teachers must be trained in increasing numbers. The research director of one large institution has told me that I would be amazed at the number of men who still do not know how to use antibiotics (penicillin, etc.) properly. At the present time it does not pay a man to stay in a medical school as a teacher; the salary rarely is sufficient to feed and rear a family.

If one takes into consideration the many thousands necessary to finance the rehabilitation of one blind person and multiplies that by the number of people saved from blindness only at those institutions which carried out their research programs on inflammatory eye diseases with Government funds-the amount of money saved this and future governments in welfare funds and income-tax exemptions would finance the institute for years to come.

Gentlemen, this is a program which is beyond the scope and ability of any private agency in the field. Only an organization such as the institute could correlate the research programs of all of the medical schools and command their respect and support. Actually, most private agencies are, by necessity, limited almost entirely to educational and rehabilitative work. Only the Government is capable of financing, coordinating, and facilitating the broad research programs necessary to save many thousands of people from preventable blindness.

It is one of the ironic tragedies of life that the more that medical science has done (and will do) to prolong life (at either end of the scale) the greater and more manifold become the other problems which arise out of that very longevity. The steps toward adding years have meant the addition of the problems of the aging eye to the other unsolved problems facing the eye man. Cataracts, glaucoma, diseases of the blood vessels and of the retina plague the population in

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