PharmacogenomicsWerner Kalow, Urs B. Meyer, Rachel F. Tyndale CRC Press, 2001 M05 8 - 424 pages "Summarizes the history of, and available applications, techniques, and approaches to, pharmacogenomics--improving efficacy and tolerance to pharmaceutical compounds, evaluating pharmacogenomics on clinical trial design, and increasing the chances of successful clinical trials and patient outcomes. Compares pharmacogenomics to pharmacogenetics, focusing on the essential components that incorporate individual genetic variations to drug regimens resulting in different responses to therapeutics." |
Contents
Historical Aspects of Pharmacogenetics | 1 |
Pharmacogenomics Biomarkers and the Promise of Personalized Medicine | 11 |
Current Status PharmacogeneticsDrug Metabolism | 33 |
Pharmacogenetics Receptors | 51 |
Pharmacogenetics of Drug Transporters | 81 |
Interethnic Differences in Drug Response | 109 |
Pharmacogenetics Clinical Viewpoints | 135 |
Tools of the Trade The Technologies and Challenges of Pharmacogenetics | 151 |
Multiplex Genotyping by Specialized Mass Spectrometry | 201 |
Serial Analysis of Gene Expression Transcriptional Insights into Functional Biology | 223 |
Proteomics | 253 |
Bioinformatics WWW Resources | 291 |
Applied Bioinformatics | 311 |
Mapping of Disease Loci | 337 |
Positional Cloning and Disease Gene Identification | 361 |
General Conclusions and Future Directions | 387 |
Molecular Diagnostics and Development of BiotechnologyBased Diagnostics | 169 |
Technologies for the Analysis of SingleNucleotide Polymorphisms An Overview | 183 |
Multiplex Fluorescent Minisequencing Applied to the Typing of Genes Encoding DrugMetabolizing Enzymes | 191 |
Index | 395 |
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Common terms and phrases
Acad Sci USA activity alleles amino acid analysis applications approach assay automated Bertilsson Biochem bioinformatics Biol biology cancer candidate gene Caucasian cDNA cell chromosome Clin Pharmacol clinical complex diseases cytochrome database debrisoquine dehydrogenase detection diagnostic disease gene ditags DNA sequence drug metabolism drug response edited effects electrophoresis encoding enzyme estrogen exon factors fragments frequency function GenBank gene expression genetic variation genotyping high-throughput Hum Genet human genome hybridization identified individuals Internet involved Kalow large number linkage disequilibrium liver loci MALDI-TOF mapping markers mass spectrometry MDR1 method minisequencing molecular mRNA multiple multiplex mutations Nat Genet Natl Acad Sci nortriptyline nucleotide oligonucleotide P-glycoprotein patients peptide Pharmaceutical Pharmacogenetics phenotype population positional cloning predict primer Proc Natl Acad profiles protein proteomics reaction receptor gene region sample single-nucleotide polymorphisms SNPs specific structure substrates targets technologies therapeutic tion tissues toxicity transcript transcriptomes transporter