Teratology in the Twentieth Century: Congenital Malformations in Humans and How their Environmental Causes were EstablishedThis book is an an up-to-date survey and summary of present knowledge and future expectations regarding the environmental causes of congenital malformations in human beings, beginning with the earliest discoveries of the 20th century up to the latest ideas and problems at its end, presents views and comments on the progress made over the century in understanding human prenatal maldevelopment. |
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Page 131
... Introduction: early radiation use 148 An irradiation-caused abnormality 149 Eye abnormalities 149 Dose, time, and effects 149 Dose matters 150 Murphy's contribution 150 Atomic radiation The Hiroshima and Nagasaki bombs 150 What ...
... Introduction: early radiation use 148 An irradiation-caused abnormality 149 Eye abnormalities 149 Dose, time, and effects 149 Dose matters 150 Murphy's contribution 150 Atomic radiation The Hiroshima and Nagasaki bombs 150 What ...
Page 132
... 170 Dose- and time-response relations 170 Animal studies with thalidomide 171 Postscript: was anyone to blame? ... 172 TESTING FOR TERATOGENICITY Proposals for drug testing 173 The procedure 174 The consequence 174 The dose-response ...
... 170 Dose- and time-response relations 170 Animal studies with thalidomide 171 Postscript: was anyone to blame? ... 172 TESTING FOR TERATOGENICITY Proposals for drug testing 173 The procedure 174 The consequence 174 The dose-response ...
Page 133
... Congenital Minamata disease 199 Source of the methylmercury 200 The Iraq epidemic 200 Matters of environment and dose 200 Studies elsewhere 200 Agent Orange Wartime use 200 Male exposure toxicity 201 Exposure of Vietnamese nationals ...
... Congenital Minamata disease 199 Source of the methylmercury 200 The Iraq epidemic 200 Matters of environment and dose 200 Studies elsewhere 200 Agent Orange Wartime use 200 Male exposure toxicity 201 Exposure of Vietnamese nationals ...
Page 148
The earlier studies were only poorly able to time pregnancy and to control and measure dose accurately, and thus could only poorly relate general and specific tissue susceptibility to dosage and prenatal stage. This was overcome in time ...
The earlier studies were only poorly able to time pregnancy and to control and measure dose accurately, and thus could only poorly relate general and specific tissue susceptibility to dosage and prenatal stage. This was overcome in time ...
Page 149
So for dose, an unknown amount had been delivered, but it must have been considerable because “the nature of the maternal ... was indicated were irradiated in the abdominal area with large doses of X-rays in the 2nd month of pregnancy.
So for dose, an unknown amount had been delivered, but it must have been considerable because “the nature of the maternal ... was indicated were irradiated in the abdominal area with large doses of X-rays in the 2nd month of pregnancy.
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Contents
CHAPTER 12 SURVEILLANCE OF CONGENITAL MALFORMATIONS | 181 |
CHAPTER 13 EPIDEMIOLOGY OF CONGENITAL MALFORMATIONS | 182 |
CHAPTER 14 HUMAN DISEASE AS TERATOGEN | 185 |
CHAPTER 15 ENVIRONMENTAL HAZARDS AND DISASTERS | 197 |
CHAPTER 16 DISEASE MEDICATION AND TERATOGENESIS | 210 |
CHAPTER 17 FOLIC ACID AND HUMAN MALFORMATIONS | 224 |
CHAPTER 18 ALCOHOL CONSUMPTION DURING PREGNANCY | 237 |
CHAPTER 19 THE ACCOMPLISHMENT AND THE EXPECTATION | 255 |
| 167 | |
CHAPTER 10 TESTING FOR TERATOGENICITY | 173 |
CHAPTER 11 TERATOLOGICAL DETOURS | 175 |
BIBLIOGRAPHY | 256 |
INDEX | 283 |
Other editions - View all
Teratology in the Twentieth Century: Congenital Malformations in Humans and ... H. Kalter Limited preview - 2003 |
Teratology in the Twentieth Century: Congenital Malformations in Humans and ... H. Kalter No preview available - 2003 |
Common terms and phrases
abnormalities abortion agents alcohol animals anomalies appeared associated birth birth defects cause Child cleft congenital malformations considered consumption death defects deficiency diabetic discussed disease dose drinking drug early editors effects embryos environmental especially et al evidence examined experimental exposed exposure fact factors fetal findings folic acid frequency Genet given growth Health hospital human important included increased indicated induced infants Kalter known Lancet later less levels Love Canal major maternal means mental minor mothers neural tube neural tube defects normal noted occurred offspring origin outcome pattern Pediatr perhaps period population possible pregnancy prenatal present prevalence prospective question records reduced relation relatively reported retardation risk rubella seems severe specific spina bifida supplementation syndrome teratogenic Teratology testing thalidomide tion usually various vitamin Warkany weeks women York