Psychoneuroendocrinology: The Scientific Basis of Clinical PracticeOwen M. Wolkowitz, Anthony J. Rothschild American Psychiatric Pub, 2008 M08 13 - 606 pages The mind-body connection is one of the hottest topics in medicine today, documented by enormous amounts of data regarding hormone effects on the brain and behavior. Yet it is only now -- with the debut of this thought-provoking volume -- that we find an up-to-date, sophisticated reference that focuses on the clinical relevance of behavioral endocrinology and is written for practicing clinicians and researchers. This wide-ranging volume shows how the principles and emerging findings of psychoneuroendocrinology can inform modern clinical practice and lead to new breakthroughs in future science and practice. Here, leading authorities -- internationally respected researchers and practicing clinicians -- review empirical findings in their areas of expertise, highlight the clinical significance of these findings, and provide, wherever appropriate, clinical guidelines for the management of patients. Beginning with a lively history of psychoneuroendocrinology (including its many false starts), this book continues on to discussions of the hypothalamic-pituitary-adrenal axis hormone system, the gonadal hormone system, and the thyroid hormone system from each of the three paths generally used for psychoneuroendocrinological investigation: Alterations in endogenous hormone levels observed in primary psychiatric illness Psychiatric concomitants or sequelae of hormonal dysregulation in primary endocrinologic illness Behavioral effects of exogenously administered hormones or hormone antagonists (both the study of the side effects of hormonal medications and the use of hormones and hormone antagonists as psychotropic medications) An unmatched diversity of topics reveals the full breadth and depth of this volume: diabetes mellitus, corticosteroid effects on mood and cognition, Cushing's syndrome and Addison's disease, oral contraceptives and estrogen replacement therapy, psychiatric illness associated with the menstrual cycle and perimenopause, postpartum behavioral changes, anabolic/androgenic steroid use, and a thorough review of thyroid function in psychiatric disorders. Particularly fascinating are sections on the role of neuropeptides and hypothalamic-releasing factors in psychiatric illness, the use of laboratory tests and imaging procedures in evaluating hormonal function in psychiatric patients, the place of newer "alternative" hormonal medications such as melatonin and DHEA in therapeutics, and a provocative and compelling final chapter on the role stress plays in precipitating illness. Designed for both clinician and researcher-scientist, this richly informative guide will also prove an invaluable addition to graduate courses in neuroscience, neuroendocrinology, the biological basis of behavior, and consultation psychiatry. Neuroscientists/neurologists, endocrinologists, obstetricians/gynecologists, internists, family practitioners, nurses, and interested laypersons round out the wide audience for this remarkable volume. |
From inside the book
Results 1-5 of 89
... disease , the authors comment on laboratory evaluations of such diseases and emphasize psychiatric responses to therapeutic endo- crine correction . The observed relationships between thyroid disease states and psychi- atric ...
... disease ( Addison's disease ) . The next year , Charles - Edouard Brown - Séquard , more famous for his de- scription of the syndrome associated with spinal cord hemisection , reported that bilateral adrenalectomy was fatal in many ...
... disease , leprosy , malaria , Addison's disease , and cancer ( Tattersall 1994 ) . Dr. Brown - Séquard reportedly believed that the ex- tract increased the " nervous force " in the body , allowing one to better fight disease . A number ...
... disease patients . Investigations con- ducted the following winter revealed that the substance was restricted to the adrenal medulla and was missing at autopsy in two patients with Ad- dison's disease ( Peart 1979 ; Welbourn 1992 ...
... disease . Psychosom Med 25 : 364–376 , 1963 Gibbons JL : Cortisol secretion rate in depressive illness . Arch Gen Psychiatry 10 : 572-575 , 1964 Gibbons JL , McHugh PR : Plasma cortisol in depressive illness . Psychiatry Res 1 : 162-171 ...
Contents
Chapter 10 | 245 |
Chapter 11 | 281 |
Chapter 12 | 303 |
Chapter 13 | 331 |
Chapter 14 | 361 |
Chapter 15 | 419 |
Chapter 16 | 445 |
Chapter 17 | 469 |
Chapter 6 | 139 |
Psychiatric Manifestations of Hyperadrenocorticism | 165 |
Chapter 8 | 174 |
Psychiatric Effects of Glucocorticoid Hormone Medications | 189 |
Chapter 9 | 205 |
Endocrine Imaging in Depression | 499 |
Chapter 19 | 513 |
Index | 547 |