Psychoneuroendocrinology: The Scientific Basis of Clinical PracticeOwen M. Wolkowitz, Anthony J. Rothschild American Psychiatric Pub, 2008 M08 13 - 606 pages The mind-body connection is one of the hottest topics in medicine today, documented by enormous amounts of data regarding hormone effects on the brain and behavior. Yet it is only now -- with the debut of this thought-provoking volume -- that we find an up-to-date, sophisticated reference that focuses on the clinical relevance of behavioral endocrinology and is written for practicing clinicians and researchers. This wide-ranging volume shows how the principles and emerging findings of psychoneuroendocrinology can inform modern clinical practice and lead to new breakthroughs in future science and practice. Here, leading authorities -- internationally respected researchers and practicing clinicians -- review empirical findings in their areas of expertise, highlight the clinical significance of these findings, and provide, wherever appropriate, clinical guidelines for the management of patients. Beginning with a lively history of psychoneuroendocrinology (including its many false starts), this book continues on to discussions of the hypothalamic-pituitary-adrenal axis hormone system, the gonadal hormone system, and the thyroid hormone system from each of the three paths generally used for psychoneuroendocrinological investigation: Alterations in endogenous hormone levels observed in primary psychiatric illness Psychiatric concomitants or sequelae of hormonal dysregulation in primary endocrinologic illness Behavioral effects of exogenously administered hormones or hormone antagonists (both the study of the side effects of hormonal medications and the use of hormones and hormone antagonists as psychotropic medications) An unmatched diversity of topics reveals the full breadth and depth of this volume: diabetes mellitus, corticosteroid effects on mood and cognition, Cushing's syndrome and Addison's disease, oral contraceptives and estrogen replacement therapy, psychiatric illness associated with the menstrual cycle and perimenopause, postpartum behavioral changes, anabolic/androgenic steroid use, and a thorough review of thyroid function in psychiatric disorders. Particularly fascinating are sections on the role of neuropeptides and hypothalamic-releasing factors in psychiatric illness, the use of laboratory tests and imaging procedures in evaluating hormonal function in psychiatric patients, the place of newer "alternative" hormonal medications such as melatonin and DHEA in therapeutics, and a provocative and compelling final chapter on the role stress plays in precipitating illness. Designed for both clinician and researcher-scientist, this richly informative guide will also prove an invaluable addition to graduate courses in neuroscience, neuroendocrinology, the biological basis of behavior, and consultation psychiatry. Neuroscientists/neurologists, endocrinologists, obstetricians/gynecologists, internists, family practitioners, nurses, and interested laypersons round out the wide audience for this remarkable volume. |
From inside the book
Results 1-5 of 87
... concentrations of potassium , sodium , and uric acid . In retrospect , it is not surprising that many of these early studies generated conflicting results . In the 1950s , as more direct measures of urinary and plasma cortisol levels ...
... concentrations in cerebrospinal fluid ( Arato et al . 1986 ; Banki et al . 1987 , 1992b ; France et al . 1988 ; Nemeroff et al . 1984 ; Risch et al . 1992 ) , although not all studies agree ( Geracioti et al . 1997 ) . Postmortem CRH ...
... concentrations State dependent . bSignificantly correlated to postdexamethasone cortisol concentrations . trations of CRH are believed to be a reflection of increased synaptic con- centrations of the peptide , likely due to central CRH ...
... concentrations of less than 5.0 μg / dL . Another method for assessing the activity of the HPA axis is the CRH stimulation test , in which CRH ( usually 100 μg or 1 μg / kg ) is adminis- tered intravenously and the ensuing ACTH ( or ẞ ...
... concentrations ( Carpenter and Bunney 1971 ; Gibbons and McHugh 1962 ) , increased levels of cortisol metabolites ( Sa- char et al . 1970 ) , and elevated 24 - hour urinary free cortisol concentra- tions . Sachar and colleagues ( 1970 ) ...
Contents
Chapter 10 | 245 |
Chapter 11 | 281 |
Chapter 12 | 303 |
Chapter 13 | 331 |
Chapter 14 | 361 |
Chapter 15 | 419 |
Chapter 16 | 445 |
Chapter 17 | 469 |
Chapter 6 | 139 |
Psychiatric Manifestations of Hyperadrenocorticism | 165 |
Chapter 8 | 174 |
Psychiatric Effects of Glucocorticoid Hormone Medications | 189 |
Chapter 9 | 205 |
Endocrine Imaging in Depression | 499 |
Chapter 19 | 513 |
Index | 547 |