in obesity management Put it to your patient this

PERSISTENT way: The basic therapeu

WEIGHT LOSS
WEEK AFTER WEEK

tic objective of obesity management is to change dietary habits built over months or years of weight accumulation. This takes time and will. Consider Didrex, the new Upjohn appetite suppressant. Happily, it elevates mood which makes dieting more acceptable. More important, it works: "persistent significant weight loss" in patients followed for as long as 20 weeks. Added to your favorite reducing regimen, 1⁄2 to 1 Didrex tablet one to three times daily is usually adequate to preclude the "weight plateau" that so often discourages dieters after a few weeks. Available as 50 mg. tablets in bottles of 100.

Upjohn

The Upjohn Company, Kalamazoo, Michigan

BRIEF BASIC

INFORMATION

Description: Didrex is the Upjohn brand of benzphetamine hydrochloride [(+)-N-benzyl-N, a-dimethyl-phenethylamine hydrochloride). A sympathomimetic compound with marked anorexic oction and relatively little stimulating effect on the CNS or cor diovascular system.

Indications Control of obesity.

Contraindications: None known. How ever, use with caution in moderate or severe hypertension, thyrotoxicosis, acute coronary disease, or cardiac decompensation,

Dosage: Initiate appetite control with 1⁄2 or 1 tablet (25 to 50 mg.) in midmorning for several days. Then adjust dosage to suit each patient's need to a maximum of 3 tablets daily (150 mg.). Side Effects. No effects on blood, urine, renal or hepatic functions have been noted Minimal side effects have been observed occasionally dry mouth, insomnia, nausea, palpitations and

nervousness.

Supplied: 50 mg., press-coated, scored tablets in bottles of 100

Photos and case histories courtesy Dr. Alan S. Rubinstein, Springfield, Illinois

Trademark-brand of benzphetamine hydrochloride, UPJOHN

(From J.A.M.A., March 25, 1961)

TWO WEEKS ON NEW DESBUTAL Gradumet
CAN MEAN THE START OF A NEW LIFE
FOR THIS DEPRESSED OBESITY PATIENT

Can anything truly take the place of will-power in obesity control? The question properly answers itself.

Yet the practical fact is this: the compulsive eater often is a casualty of many diets sincerely begun, and abjectly discarded. What she lacks is not the "will" to lose weight-this may be the most pressing need in her life; she lacks the conviction that anything can change the pattern of her dietary failures.

Here is where Desbutal Gradumet can make a critical difference in treatment. The product combines Desoxyn (a stimulant) and Nembutal" (a sedative). Is this a contradiction of effects? In practice, quite the opposite.

DESBUTAL
Gradumet

Each drug comple

ments the other. Ty

pically, only unwanted effects are cancelled. The mood brightens, but euphoric "peaks" -jitters-simply don't

occur. Steadily, surprisingly, appetite diminishes. The patient feels, perhaps for the first time, that she's going to win this diet.

In the Gradumet vehicle, therapy is refined even more. The patient takes a single Gradumet in the morn ing. Within seconds, the Gradumet release process begins. Throughout the daytime hours the patient is receiving the drugs at a controlled rate. There are no forgotten doses, no midafternoon letdown. One dose, all day. For complete indications, precautions, dosage, etc., send for the official literature.

Your Abbott man has samples of both Desbutal 10 and 15. Check with him. Th
new Gradumet form may be the answer for the patient who can't—or won't-
stay on medication.

• Desbutal Gradumet-Desoxyn and Nembutal in Long-Release Dose Form, Abbott
Desoxyn Methamphetamine Hydrochloride, Abbott

• Nembutal Sodium-Pentobarbital Sodium, Abbott

102201

ABBOTT

(From J.A.M.A., March 11, 1961)

"crash diets"

do not solve the basic patient problem:
habitual overeating

In the treatment of chronic obesity, "fad diets" are not the
answer. Your patients may suffer adverse somatic as well as psychic
effects from alternating weight loss and gain.

At the conclusion of a "crash-diet" program, the patient often
falls back into familiar habits of overeating. The problem,
therefore, remains the same.

The process of eliminating pounds in the chronically obese
should be gradual. To accomplish this, obviously, new patterns
of eating must be established.

BAMADEX tablets help the patient be satisfied on a diet which will
cause him to lose weight. BAMADEX tablets combine two specific agents
to overcome the habitual overeating in the chronically obese...
the outstanding appetite suppressant, d-amphetamine, balanced with
the tranquilizer, meprobamate. BAMADEX tablets help the recalcitrant
patient keep within his prescribed caloric limits. It does this by
curbing between-meal hunger, fatigue, nervousness, insomnia, and
dizziness, which may lead to failure in diet reduction.

BAMADEX

meprobamate with d-amphetamine sulfate Lederle

Lederle

helps them
to help themselves
to less!

BAMADEX Tablets: Each coated tablet (pink) contains: d-amphetamine
sulfate, 5 mg.; meprobamate, 400 mg. dosage: 1 tablet one-half to one hour
before each meal. Higher dosage may be required in certain cases.
precautions: Use with caution in patients hypersensitive to sympathomimetic
compounds, who have coronary or cardiovascular disease, or who
are severely hypertensive. supplied: Bottles of 100 and 1,000.

LEDERLE LABORATORIES A Division of AMERICAN CYANAMID COMPANY Pearl River, New York

Controls compulsive overeating

CURBS APPETITE... RELIEVES TENSION HUNGER...

TRANQUILIZES "DIET JITTERS"

Why do so many overweight patients so often break their diets?

The reason is usually tension.1.2.3 Appetrol has been formulated to help you solve this problem. Appetrol provides dextro-amphetamine to curb your patient's appetite. Even more important, it provides meprobamate to control compulsive overeating, to ease the frustration of the dietary regimen and to minimize the jittery effects of amphetamine.

Usual dosage: 1 or 2 tablets one-half to 1 hour before meals. Each tablet contains: 5 mg. dextro-amphetamine sulfate and 400 mg. meprobamate.

Available: Bottles of 50 pink, scored tablets.

Thus, Appetrol does more than other anorectics which merely suppress appetite. Appetrol alse tranquilizes tension hunger to give more complete control of compulsive overeating. Your patients find it easier to stay on their diets - even during prolonged periods.

References: 1. Freed, S. C.: Psychic factors in the development treatment of obesity. J.A.M.A. 133:369, Feb. 8, 1947, 2. Keckow 1 Group psychotherapy with the obese. Paper read before The Acade Psychosomatic Medicine, Oct. 1958. 3. Plotz, M.: Modern mamp obesity-the "social diet." J.A.M.A. 176:1513, July 25, 1959

Appetrol

DEXTRO-AMPHETAMINE + MEPROBANATE

for appetite control

WALLACE LABORATORIES/ Cranbury, N. J.

SYNTHETIC PENICILLINS

(From J.A.M.A., April 30, 1960)

ALPEN is the oral penicillin that provides on a fasting stomach peak antibiotic blood levels approximately twice as high as oral potassium penicillin V... and significantly higher than I. M. penicillin G.

Some strains of staphylococci resistant to other penicillins exhibit in vitro sensitivity to potassium phenethicillin.

ALPEN has greater freedom from the G. I. sequelae (overgrowth of resistant flora) sometimes observed with broad spectrum -mycins. ALPEN gives much higher antibiotic levels within the first hour of ingestion by the well-tolerated oral route.

WHEN TO USE ALPEN Recommended in the treatment of infections caused by pneumococci, streptococci, gonococci, corynebacteria, and penicillin-sensitive staphylococci.

HOW TO USE ALPEN Depending on the severity of the infection, 125 mg. (200,000 units) or 250 mg. (400,000 units) three times daily may be used. In more severe or stubborn infections, a dosage of 500 mg. (800,000 units) t.i.d. may be employed. In beta hemolytic streptococcal infections, treatment should be continued for at least ten days.

PRECAUTIONS The usual precautions in the administration of oral perficillin should be observed. For further details see package literature.

Tablets: 125 mg. and 250 mg., bottles of 25 and 100. Powder for Oral Solution (lemon-lime flavored), 1.5 Gm. bottle (125 mg. per 5 cc. teaspoonful).

this is the tablet that sincs Ligher pook

!

antikolic MooMorele

HIGHER LAN I. 1. FENICHIIN G HIGHER THAN POTASSIUM FIMCILLIN V

ALPEN

ALPEN potassium phenethicillin

Schering