Risk Assessment of Chemicals: An Introduction

Front Cover
C.J. van Leeuwen, J.L.M. Hermens
Springer Science & Business Media, 1995 M10 31 - 374 pages
In recent years many developments have taken place in promote co-operation between governments and other the field of risk assessment of chemicals. Many reports parties involved in chemical safety and to provide policy have been published by national authorities, industries guidance with emphasis on regional and subregional co and scientific researchers as well as by international bod operation. The Inter-Organization Programme for the ies such as the European Union, the Organization of Sound Management of Chemicals (IOMC) was estab Economic Cooperation and Development (OECD) and lished in 1995 and provides a mechanism for the six par the joint International Programme on Chemical Safety ticipating organizations (UNEP, ILO, FAO, UNIDO,WHO (IPCS) of the World Health Organization (WHO), the and OECD) to better co-ordinate policies and activities in International Labour Organization (lLO), and the United the field of chemical risk management. Nations Environment Programme (UNEP). The present book is an introduction to risk assessment of The development and international harmonization of risk chemicals. It contains basic background information on assessment methods is an important challenge. In sources, emissions, distribution and fate processes for Agenda 21 of the United Nations Conference on exposure estimation. It includes dose-effects estimation Environment and Development (UNCED), chapter 19 is for both human health related toxicology and ecotoxicol entirely devoted to the management of chemicals. For ogy as well as information on estimation methodologies. one of its recommendations, i. e.

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Contents

1 GENERAL INTRODUCTION
1
121 Hazard identification step 1
3
123 Exposure assessment step 3
4
125 Risk classification step 5
5
126 Riskbenefit analysis step 6
6
127 Risk reduction step 7
7
128 Monitoring step 8
9
14 How risks are expressed
10
54 Toxicity tests
150
542 Acute single dose toxicity
153
543 Repeated dose studies subacute and subchronic toxicity
155
544 Chronic studies
157
545 Carcinogenicity
159
546 Genotoxicity testing
161
547 Reproductive and developmental toxicity
163
548 Other specific studies
165

15 Perception of risks
11
16 Uncertainties n risk management
12
17 Model validation
13
19 Contents of the book
14
2 EMISSIONS OF CHEMICALS
19
222 Desirable and undesirable substances
20
23 Emissions and sources
21
232 Types of emissions and sources
23
234 Emissions in relation to risk assessment
25
24 Data availability and generation
26
242 Specific calculations
27
243 The application of emission factors
29
3 TRANSPORT ACCUMULATION AND TRANSFORMATION PROCESSES
37
322 Equilibrium partitioning between phases
38
323 Intramedia transport in air
41
325 Intermedia transport
44
33 Bioaccumulation
50
332 Aquatic bioaccumulation processes
51
333 Factors affecting bioconcentration
57
334 Biomagnification
61
335 Accumulation in terrestrial plants
64
336 Accumulation in terrestrial invertebrates
66
337 Accumulation in mammals and birds
68
338 Methods for measuring terrestrial bioaecumulation
69
342 Hydrolysis
70
343 Oxidation
71
344 Reduction
73
345 Photochemical degradation
74
346 Methods for measuring abiotic degradation
76
352 Aerobic biodegradation and metabolic pathways
77
353 Anaerobic biodegradation
78
354 Reasons for the environmental persistence of chemicals
79
355 Kinetics of biodegradation
81
356 Assessing biodegradation and biodegradation rates
82
Biotransformation
84
364 Factors influencing enzyme activity
90
365 Methods to measure biotransformation
92
366 Biotransformation of some specific groups of compounds
94
367 Enzyme inhibition and induction
96
368 Effect of enzyme induction on toxicity
97
4 EXPOSURE MODELLING
101
414 Model types
104
415 Models versus measurements
105
416 Further reading
106
423 Some examples of operational models
107
424 Application of a local air model in the risk assessment of new and existing chemicals
108
425 Input requirements for air models
110
43 Water models
111
433 Dispersion models
112
434 Compartment models
113
436 Data requirements for water models
115
442 Fate processes in soil modelling
116
443 Model types
117
444 Use of soil models in the risk assessment of new and existing chemicals
118
445 Data requirements for soil models
119
45 Multimedia models
120
453 Data requirements for multimedia models
122
455 Available multimedia models and calculations
123
456 Sample calculations
124
46 Human exposure through the environment
127
462 Choice of exposure scenario
129
463 Direct exposure through the environment
130
465 Derivation of the total daily uptake and sample calculations
132
47 Consumer and occupational exposure
134
472 Consumer exposure
135
473 Occupational exposure
138
5 TOXICITY TESTING AND HUMAN HEALTH
145
53 Strategies in toxicity testing
147
55 Safety evaluations for humans
167
553 Mixtures of chemicals
169
6 ECOTOXICOLOGICAL EFFECTS
173
Differences between HRA and ERA
174
623 Spatial scales
175
624 Temporal scales
176
625 Complexity of exposure
177
63 Aquatic toxicity
182
632 Shortterm toxicity
184
633 Longterm toxicity
189
634 Population dynamics
194
635 Multispecies studies
198
64 Sediment toxicity
202
642 Exposure systems
203
644 Sediment toxicity tests
206
65 Terrestrial toxicity
208
653 Tests with bacteria and plants
211
655 Tests with birds and mammals
213
656 Multispecies tests
215
66 Factors modifying toxicity
216
663 Biotic factors
219
672 Mixture toxicity studies
220
68 Derivation of PNECs
221
681 Preliminary effects assessment
222
682 Refined effects assessment
223
683 Effects of secondary poisoning
226
684 Comprehensive effects assessment
229
7 PROPERTIES OF CHEMICALS AND ESTIMATION METHODOLOGIES
237
723 Techniques
241
73 Basic properties of estimation models
242
731 Octanolwater partition coefficient
243
732 Water solubility
246
733 Vapour pressure
249
734 Henrys law constant
250
735 Acid dissociation constant
252
74 Environmental fate nad estimation models
254
742 Chemical degradation
259
74 3 Biodegradation
261
744 Soil sorption
265
75 Effects and estimation models
269
752 Human health effects
276
76 Computer programs and databases
279
8 PROCEDURES OF HAZARD AND RISK ASSESSMENT
289
822 New substances
290
823 Existing substances
291
824 Plant protection products and biocides
292
83 Elements of risk assessment
293
832 Protection goals
294
841 Data requirements
295
843 Data quality and selection
296
85 Exposure assessment
297
852 Emissions
300
854 Exposure and intake
303
855 Occupational and consumer exposure
305
856 Sample calculations
306
86 Effects assessment
310
863 Atmospheric risks
314
864 Effects on human health
315
865 Sample calculations
319
87 Risk characterization
320
873 Human health risks
322
875 Sample calculations
324
882 Environmental risk evaluation
325
883 Human risk evaluation
327
884 Risk reduction
329
GLOSSARY
335
INDEX
359

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