Congenital Diseases and the EnvironmentP. Nicolopoulou-Stamati, L. Hens, C.V. Howard Springer Science & Business Media, 2007 M06 10 - 472 pages In recent years, increasing attention and resources have been brought to bear on the relationship between the environment and congenital diseases. These diseases were previously thought to be mostly due to genetic causes. Even though the importance of genes as factors in causation is accepted, environmental factors seem to be implicated just as strongly. This book explores some further concepts that have arisen from more recent perceptions of environmental effects and their possible interactions with living systems. Amongst the topics discussed are: -effects of prenatal exposure to toxic chemicals -intra-uterine exposure to drugs -effects of endocrine disrupters -environmental risk and sex ratio in newborns -surveillance of environmental impact -research and policy Discussion and presentation of old and novel ideas is targeted at developing a more holistic and united perception of the interaction between congenital diseases and the environment. |
Contents
| 1 | |
| 7 | |
| 12 | |
| 21 | |
Recommendations for further research in developmental toxicology | 31 |
CONGENITAL DEFECTS OR ADVERSE DEVELOPMENTAL | 37 |
Summary of some effects found in both humans and wildlife | 67 |
EPIDEMIOLOGICAL METHODS | 88 |
References | 241 |
Semen quality and testicular cancer | 246 |
Effects of environmental antiandrogens on the reproductive development | 260 |
Conclusions | 273 |
Toxic effect of antiandrogenic compounds on male reproductive health | 286 |
ENVIRONMENTAL RISK AND SEX RATIO IN NEWBORNS | 295 |
Dose response in teratology | 302 |
Chernobyl 309 6 1 Radioactive clouds and whole body radioactivity | 309 |
Study designs | 97 |
Problems in environmental epidemiology when studying its effects | 113 |
Conclusions | 121 |
SURVEILLANCE OF ENVIRONMENTAL IMPACT | 131 |
EUROCAT surveillance of environmental impact | 137 |
CLINICAL TERATOLOGY | 147 |
Conclusions 157 References 15 | 159 |
J G KOPPE M LEIJS G TENTUSSCHER AND P D BOER | 166 |
Conclusion | 178 |
Congenital disorders | 185 |
Does European pesticide policy protect our health? | 196 |
References | 203 |
ASSOCIATION OF INTRAUTERINE EXPOSURE TO DRUGS | 207 |
ENDOCRINE DISRUPTER EXPOSURE AND MALE CONGENITAL | 225 |
FUNCTIONAL | 321 |
Discussion | 334 |
Introduction | 340 |
Discussion | 350 |
CONGENITAL ANOMALIES IN THE BRITISH ISLES | 359 |
Variations in the prevalence of congenital anomalies in the British Isles | 368 |
Use of data from congenital anomaly registers in environment and health | 371 |
EUROPEAN UNIONFUNDED RESEARCHON ENDOCRINE | 378 |
ENVIRONMENTAL IMPACTS ON CONGENITAL ANOMALIES | 409 |
Introduction | 410 |
Mechanisms causing congenital anomalies | 429 |
References | 443 |
INDEX | 457 |
Other editions - View all
Congenital Diseases and the Environment P. Nicolopoulou-Stamati,L. Hens,C.V. Howard No preview available - 2007 |
Congenital Diseases and the Environment P. Nicolopoulou-Stamati,L. Hens,C.V. Howard No preview available - 2010 |
Common terms and phrases
action activity addition agents androgen animals assessment associated birth defects cancer cause cells chemicals communication compared concern congenital abnormalities congenital anomalies congenital malformations contaminants countries cryptorchidism decrease developmental dioxins disease dose drugs effects embryos endocrine disrupters Environ environmental epidemiological estrogenic et al EUROCAT European evidence example exposed exposure factors fetal Figure function genetic Greece Health Health Perspect higher hormone human hypospadias identify important incidence increased individual infant Italy lead levels living major male malformations maternal mechanisms mortality mothers neural tube observed occur organs PCBs period pesticides placenta pollutants population possible potential pregnancy prenatal present prevalence production projects rates ratio reduced regions registers reported reproductive response risk selected specific spontaneous abortions Statistical studies substances suggested syndrome Table teratogenic Teratology testicular testing thalidomide thyroid toxicity Toxicol
Popular passages
Page 127 - MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study.
Page 77 - Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p.-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat, J Toxicol Ind Health.
Page 125 - Maitland, I., Richardson, S., Wakefield, J. and Jarup, L. (2001) Risk of adverse birth outcomes in populations living near landfill sites, British Medical Journal, 323: 363-8.
Page 275 - Kupfer, D. (1978). Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites. Role of hepatic mono-oxygenase in methoxychlor activation.
Page 278 - RE (1991). 2,3,7,8-Tetrachlorodibenzo-pdioxin inhibits steroidogenesis in the rat testis by inhibiting the mobilization of cholesterol to cytochrome P450SCC. Toxicol. Appl. Pharmacol.
Page 78 - Vonk, A., 2003, Atrazineinduced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): Laboratory and field evidence, Environ.
Page 472 - ISBN 0-7923-3500-7 4. AV Gheorghe and M. Nicolet-Monnier: Integrated Regional Risk Assessment. Volume I: Continuous and Non-Point Source Emissions: Air, Water, Soil. 1995 ISBN 0-7923-371 7-4 Volume II: Consequence Assessment of Accidental Releases.