Retinoids in OncologyWaun Ki Hong, Reuben Lotan CRC Press, 1993 M05 11 - 352 pages This reference provides a comprehensive overview of recent developments in basic research that are relevant to the application of retinoids for cancer prevention and treatment.;Organized in a quick-referral format by specific disease site, this book: describes the effects of retinoids on squamous differentiation in normal, pre-malignant, and malignant epithelial tissues; addresses the mechanisms by which cultured keratinocytes respond to retinoids; considers the antitumor activity of combination therapy with retinoids and cytokines; reviews the toxicity profiles of the vitamin A molecule and the synthetically derived retinoid compounds and their effects on humans; examines the use of retinoids in the prevention of basal cell carcinoma and squamous cell carcinoma (SCC) and in the therapy of advanced SCC; and summarizes data on the potential of retinoids to prevent epithelial cancer, to act as adjuvants to current therapies in early stages of the disease and to aid in the management of both solid tumours and hematologic malignancies.;A guide for the many disciplines involved in the preclinical studies and direct care of cancer patients, this book serves as useful reading for clinical, surgical and radiation oncologists; clinical immunologists; dermatologists; obstetricians/gynaecologists; haematologists; otolaryngologists; internists; nutritionists; and pulmonary-disease specialists. |
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Contents
Retinoids and Squamous Cell Differentiation | 43 |
Role of Nuclear Retinoic Acid Receptors in the Control | 73 |
Modulation of Growth and Differentiation by Combined | 89 |
Retinoids in Experimental Oncology | 109 |
Clinical Toxicity of Retinoids | 127 |
Retinoids in Leukemia and Myelodysplastic Syndromes | 147 |
Retinoids in Skin Cancer | 179 |
Retinoids in Head and Neck Cancer | 203 |
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Common terms and phrases
13-cis-retinoic acid Acad acitretin activity acute promyelocytic leukemia agents all-trans all-trans-retinoic acid B-carotene binding protein Biol Chem bladder cancer Cancer Res carcinogen carcinogenesis cell lines cellular cervical chemoprevention chemotherapy clinical trials combination cultured cytokines dietary disease dose drug effects of retinoids epidermal keratinocytes epithelial cells etretinate expression fenretinide gene Goodman DS growth hamster head and neck Hong WK induced inhibition intake interferon involucrin isotretinoin Jetten keratin keratinocytes lesions leukemia cells leukoplakia levels lipid Lippman SM lung cancer malignant mammary markers metabolism metabolite mice mRNA myeloid Natl Cancer Inst normal Oncology oral patients placebo plasma premalignant prevention proliferation recurrence reported response rate retinaldehyde retinoic acid receptor retinol-binding protein retinyl acetate retinyl ester risk role second primary tumors serum skin cancer squamous cell carcinoma squamous differentiation studies synthetic retinoids therapy tion tissue toxicity transcription transglutaminase treated treatment tretinoin vitamin vitro vivo
Popular passages
Page 318 - Sporn, MB, Dunlop, NM , Newton, DL, and Smith, JM , Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids), Fed.